The 65th American Society of Hematology (ASH) Annual Meeting and Exposition showcased research from authors affiliated with the University of Illinois Cancer Center, University of Illinois Chicago and UI Health. Below is a list of their work featured at ASH, which ended December 12.
Charles E Ayemoba1,2*, Sen Zhang, PhD1*, Anna M Di Staulo1,2*, Thomas G Henderson3*, Mary Menhart3*, Alex M Dittmar1*, Konstantinos Chronis, PhD3* and Sandra Pinho, PhD1
1Department of Pharmacology & Regenerative Medicine, University of Illinois at Chicago, Chicago, IL
2University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, IL
3Department of Biochemistry & Molecular Genetics, University of Illinois at Chicago, Chicago, IL
Menopause in Sickle Cell Disease: Unchartered Territory
Marwah Farooqui, DO1, Elisa Martinez, MD candidate2*, Kaitlin Sung, MD candidate3*, Marianna Vakaki, MD candidate2*, Kayla Gross, MD candidate2*, Xu Zhang, PhD4*, Victor R. Gordeuk, MD5 and Gelila Goba, MD, MPH6*
1Hematology Oncology, University of Illinois, Burr Ridge, IL
2College of Medicine, University of Illinois, Chicago
3UIC College of Medicine, Chicago, IL
4UIC, Chicago, IL
5Department of Medicine, University of Illinois Chicago, Chicago, IL
6Department of Obstetrics & Gynecology, University of Illinois, Chicago
Chenguang Wang1*, Nermin Kady1*, Ashley Wolfe1*, Ira Maine1*, Suhaib Abdelrahman1*, Vanessa Perez Silos2*, Carlos A. Murga-Zamalloa, MD3 and Ryan A. Wilcox, MD4
1University of Michigan, Ann Arbor, MI
2Department of Pathology, University of Illinois Chicago, Chicago, IL
3University of Illinois Chicago, Chicago, IL
4Division of Hematology/Oncology, University of Michigan Cancer Center, Ann Arbor, MI
Zhangli Peng, PhD1, Alexis Moreau2*, François Yaya3*, Huije Lu4*, Anagha Surendranath3*, Anne Charrier3*, Benoit Dehapiot3*, Emmanuelle Helfer3* and Annie Viallat3*
1Department of Biomedical Engineering, University of Illinois Chicago, Chicago, IL
2Yale University, New Haven, CT
3Aix Marseille Université, Marseille, France
4University of Illinois Chicago, Chicago, IL
Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons (Papio anubis)
Vinzon Ibanez1*, Kestis Vaitkus1*, Robert Molokie, MD2, Yogenthiran Saunthararajah, MD3 and Donald Lavelle1
1University of Illinois Chicago, Jesse Brown VA Medical Center, Chicago, IL
2Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
3Cleveland Clinic Case Western Reserve Univ., Cleveland, OH
Xu Zhang, PhD1*, Binal Shah, PhD1*, Jin Han, PharmD2*, Jose A. Lopez, M.D3, Dominic W. Chung, Ph.D3*, Junmei Chen, PhD3, Victor R. Gordeuk, MD4 and Santosh L. Saraf, MD5
1Department of Medicine, University of Illinois At Chicago, Chicago, IL
2College of Pharmacy, University of Illinois Chicago, Chicago, IL
3University of Washington, Bloodworks Research Institute, Seattle, WA
4Department of Medicine, University of Illinois Chicago, Chicago, IL
5Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
Alkaline Phosphatase As a Marker for Acute Complications in Sickle Cell Disease
Jin Han, PharmD1*, Xu Zhang, PhD2*, Binal Shah, PhD3*, Santosh L. Saraf, MD4 and Victor R. Gordeuk, MD5
1College of Pharmacy, University of Illinois Chicago, Chicago, IL
2UIC, Chicago, IL
3Department of Medicine, University of Illinois At Chicago, Chicago, IL
4Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
5Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
Markers of Glycemic Control in Adults with Sickle Cell Disease
Ryan Sun, MD1*, Brian Layden, MD1*, Joseph Zapatar, MD1*, Bill Galanter, MD1*, James Lash, MD2*, Jin Han, PharmD3*, Victor R. Gordeuk, MD4 and Santosh L. Saraf, MD5
1University of Illinois at Chicago, Chicago, IL
2University of Illinois College of Medicine At Chicago, Chicago, IL
3College of Pharmacy, University of Illinois Chicago, Chicago, IL
4Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
5Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
Lucas Maahs, MD1, Matthew Koshy, MD2*, Karen Sweiss, PharmD3, Kang-hyun Ahn, PhD4*, Zhengjia Chen, PhD5*, Chukwuemeka Uzoka, MD6, Carlos Galvez, MD6, Paul Rubinstein, MD1*, John Quigley, MD6, Santosh L. Saraf, MD7, Ana Maria Avila Rodriguez, MD1, Bulent Aydogan, PhD8*, Nadim Mahmud, MBBS, PhD9 and Damiano Rondelli, MD6*
1Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
2Department of Radiation Oncology, University of Illinois at Chicago, Chicago, IL
3Department of Pharmacy Practice, University of Illinois at Chicago, Hinsdale, IL
4Department of Radiation Oncology, University of Illinois at chicago, Chicago, IL
5Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, IL
6Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
7Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
8Department of Radiation Oncology, University of Chicago, Chicago, IL
9Division of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine, Chicago, IL
Robert Molokie, MD1, Santosh L. Saraf, MD1,2, Lani Krauz3*, Michael Pacini, PharmD4*, David Chan, PharmD4*, Alana Aziz-Bradley4*, Rebeca Gansari4*, Taif Hassan5*, Philip Woost6*, James Jacobberger6*, Victor R. Gordeuk, MD7, Donald E. Lavelle, PhD8, Joseph DeSimone, PhD5,9* and Yogenthiran Saunthararajah, MD10
1Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
2Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
3University of Illinois at Chicago, Chicago, IL
4Department of Medicine, University of Illinois Hospital and Health Sciences System, Chicago
5University of Illinois At Chicago, Chicago, IL
6Case Western Reserve University, Cleveland, OH
7Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
8Department of Medicine, University of Illinois at Chicago, Chicago, IL
9University of Illinois at Chicago VA Chicago West Side Division, Chicago, IL
10Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
Santosh L. Saraf, MD1, Shehu Umar Abdullahi, MD2*, Adeseye Michael Akinsete, MBBS3*, Foluke A Fasola4*, Modupe Idowu, MD5, Sharon Pennington, MD6, William B Ershler, MD7, Marshall Patrick Stagg8*, Wai Chin9*, Eric Zimmerman9*, Adeyemi Adenola10*, Mira Patel Pochron9* and Eleanor A Lisbon, MD10
1Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
2Department of Pediatrics, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria
3College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria
4University of Ibadan/University College Hospital, Idi-Araba, Ibadan, Nigeria
5Department of Hematology and Oncology, The University of Texas Health Science Center McGovern Medical School, Houston, TX
6Mississippi Center For Advanced Medicine, Madison, MS
7Inova Schar Cancer Institute, Fairfax, VA
8Baton Rouge General Medical Center, Baton Rouge, LA
9Pfizer Inc, South San Francisco, CA
10Pfizer Inc, New York, NY
Pre-Clinical Activity of Navitoclax in TCR-Driven and Non-ALCL Mature T-Cell Lymphomas
Xiangrong Geng1*, Chenguang Wang1*, Ashley Wolfe1*, Ira Maine1*, Suhaib Abdelrahman1*, Carlos A. Murga-Zamalloa, MD2 and Ryan A. Wilcox, MD3
1University of Michigan, Ann Arbor, MI
2University of Illinois Chicago, Chicago, IL
3Division of Hematology/Oncology, University of Michigan Cancer Center, Ann Arbor, MI
Nermin Kady1*, Chenguang Wang1*, Ashley Wolfe1*, Ira Maine1*, Suhaib Abdelrahman1*, Carlos A. Murga-Zamalloa, MD2 and Ryan A. Wilcox, MD3
1University of Michigan, Ann Arbor, MI
2University of Illinois Chicago, Chicago, IL
3Division of Hematology/Oncology, University of Michigan Cancer Center, Ann Arbor, MI
GATA-3 Dependent Gene Transcription Is Impaired upon HDAC Inhibition
Xiangrong Geng1*, Chenguang Wang1*, Thilini Perera2*, Badeia Saed2*, Ying Hu2*, Ashley Wolfe1*, John C Reneau, MD, PhD3, Carlos A. Murga-Zamalloa, MD2 and Ryan A. Wilcox, MD4
1University of Michigan, Ann Arbor, MI
2University of Illinois Chicago, Chicago, IL
3The James Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH
4Division of Hematology/Oncology, University of Michigan Cancer Center, Ann Arbor, MI
Ying He, PhD1*, Xiao Guo1*, Robert Molokie, MD2,3 and Zaijie Jim Wang, PhD1*
1University of Illinois at Chicago, Chicago, IL
2Jesse Brown VA Medical Center, Chicago, IL
3Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
Free from Drug Therapy in Multiple Myeloma (FREEDMM): MRD-Based Cessation of Maintenance
Ana Maria Avila Rodriguez, MD1, Danny Hadidi, MD1*, Craig C. Hofmeister, MD2, John Quigley, MD1, Maria Zappia, PhD3*, Maxim Frolov, PhD3*, Elizaveta Benevolenskaya, PhD3*, Matias Eugenio Sanchez, MD1, Shrihari Kadkol, PhD4*, Douglas Sborov, MD, MS5, Damiano Rondelli, MD1*, Chukwuemeka Uzoka, MD1 and Karen Sweiss, PharmD6
1Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
2Department of Hematology & Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
3Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL
4University of Illinois At Chicago, Chicago, IL
5University of Utah School of Medicine, Salt Lake City, UT
6Department of Pharmacy Practice, University of Illinois at Chicago, Hinsdale, IL
Lisa Baumann Kreuziger, MD, MS1, Taeim Kwon, BS2*, Lana Wahid, MD3*, Raj S. Kasthuri, MD4, Andrei L. Kindzelski, MD, PhD5*, M. Margaret Knudson, MD6*, Jerry Krishnan, MD, PhD7*, Gervasio Lamas, MD8*, Eric Leifere, PhD9*, Jose Lopez-Sendon, MD, PhD10*, Peter J Miller, MD11*, Bela Patel, MD12*, Alexandra J Weissman, MD, MS, MPH13*, John Quigley, MD14, Deborah Siegal, MD, MSc15, Tracy Y Wang, MD, MHS, MSc16*, Kevin J Anstrom, PhD, MS2* and Thomas L. Ortel, MD, PhD17
1Versiti, Menomonee Falls, WI
2University of North Carolina, Chapel Hill, NC
3Duke University, Durham, NC
4Univ. of North Carolina at Chapel Hill Division of Hematology/Oncology, Chapel Hill, NC
5National Institutes of Health, Bethesda, MD
6UCSF, San Francisco, CA
7University of Illinois Chicago, Chicago, IL
8Mount Sinai Medical Center, Miami Beach, FL
9NHLBI, Bethesda, MD
10IdiPaz Research Institute, Universidad Autonoma de Madrid, Madrid, Spain
11Wake Forest School of Medicine, Winston-Salem, NC
12University of Texas Health Science Center Houston, Houston, TX
13University of Pittsburgh, Pittsburgh, PA
14Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
15University of Ottawa, Ottawa, ON, Canada
16PCORI, Washington, DC
17Division of Hematology, Department of Medicine, and Department of Pathology, Duke University Medical Center, Durham, NC
Eshana Shah, MD1, Ana Maria Avila Rodriguez, MD2, Jerry W Luo, MD, MS2*, Joanna Cwykiel, MD3*, Tasha Chasson, MSW, LCSW2*, Elizabeth Raigoza, LCSW2*, Alexander Bratslavsky2*, Peter Doukas, MD3*, Reanna Williams, PA-C3*, Christa Jackowicz, PA-C3*, Hyein Lee, RN3*, Talha Khan, PharmD3*, Kimberly Webb, RN3*, Yasmin Abaza, MD3, Jessica K. Altman, MD4, Betina Yanez, PhD3*, John Quigley, MD2, Carlos Galvez, MD2, Shira N. Dinner, MD3, Kim Johnson, MPH, PHd5*, Madelyn Burkart, MD3 and Irum Khan, MD3
1School of Medicine, Yale University, New Haven, CT
2Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
3Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
4Northwestern University, Chicago, IL
5Brown School at Washington University, St Louis, MO
Lisa Baumann Kreuziger, MD, MS1, Taeim Kwon, BS2*, Lana Wahid, MD3*, Raj S. Kasthuri, MD4, Andrei L. Kindzelski, MD, PhD5*, M. Margaret Knudson, MD6*, Jerry Krishnan, MD, PhD7*, Gervasio Lamas, MD8*, Eric Leifere, PhD9*, Jose Lopez-Sendon, MD, PhD10*, Peter J Miller, MD11*, Bela Patel, MD12*, Alexandra J Weissman, MD, MS, MPH13*, John Quigley, MD14, Deborah Siegal, MD, MSc15, Tracy Y Wang, MD, MHS, MSc16*, Kevin J Anstrom, PhD, MS2* and Thomas L. Ortel, MD, PhD17
1Versiti, Menomonee Falls, WI
2University of North Carolina, Chapel Hill, NC
3Duke University, Durham, NC
4Univ. of North Carolina at Chapel Hill Division of Hematology/Oncology, Chapel Hill, NC
5National Institutes of Health, Bethesda, MD
6UCSF, San Francisco, CA
7University of Illinois Chicago, Chicago, IL
8Mount Sinai Medical Center, Miami Beach, FL
9NHLBI, Bethesda, MD
10IdiPaz Research Institute, Universidad Autonoma de Madrid, Madrid, Spain
11Wake Forest School of Medicine, Winston-Salem, NC
12University of Texas Health Science Center Houston, Houston, TX
13University of Pittsburgh, Pittsburgh, PA
14Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
15University of Ottawa, Ottawa, ON, Canada
16PCORI, Washington, DC
17Division of Hematology, Department of Medicine, and Department of Pathology, Duke University Medical Center, Durham, NC
Sergiy Klymenko1*, Irina Korenkova2*, Oleksandr Lysytsia3*, Menachem Bitan, MD, PhD4*, Olena Lukianets, MD5*, Jan M. Zaucha6*, Joannis Mytilineos7*, Andreas Hochhaus, MD8, Mats Heyman9, Francois Guilhot, MD10*, Natacha Bolanos11*, Roman Kuts, MD12*, Hildegard T. Greinix, MD13, Isabel sanchez-Ortega14*, Mickey Boon Chai Koh, MD, PhD15*, Bohdan Medvediev16*, Susan Landgraf17*, Rüdiger Hehlmann, MD 18, Mahmoud Aljurf, MD19*, Torsten Haferlach, MD, PhD20, Arnold Ganser21, Anna Maria Sureda Balari, MD, PhD22, Damiano Rondelli, MD23* and Dietger W. Niederwieser, MD24
1Feofaniya Hospital, Kyiv, UKR
2Kyiv Bone Marrow Transplantation Center, 119 Peremohy avenue, Kyiv, kyiv, Ukraine
3National Specialized Children’s Hospital “Ohmatdyt”, Kyiv, Ukraine
4Meuhedet HMO and The Hebrew University of Jerusalem, Jerusalem, Israel
5Clinical Center of Oncology, Hematology, Transplantology and Palliative Care of Cherkasy Oblast Council,, Cherkasy, Ukraine
6Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland
7Zentrales Knochenmarkspenderregister Deutschlands (ZKRD), Ulm, Germany
8Department Hematology and Oncology, Klinik für Innere Medizin II, Jena, Germany
9Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
10University of Poitiers, Poitiers, France, FRA
11Lymphoma coalition, Madrid, Spain
12Ukrainian Bone Marrow Donor Registry, Kyiv, Ukraine
13Division of Hematology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
14EBMT executive Office, Barcelona, Spain
15St George’s University Hospitals, London, United Kingdom
16Kyiv Bone Marrow Transplantation Center, Kyiv, Ukraine
17St. Georg Hospital, Leipzig, Germany
18ELN-Foundation, Weinheim, Germany
19King Faisal Specialist Hospital & Research Centre, Oncology (Section of Adult Haematolgy/BMT) – Riyadh, Saudi Arabia, Riyadh, Saudi Arabia
20MLL Munich Leukemia Laboratory, Munich, Germany
21Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany
22Clinical Hematology Department, Institut Català d’Oncologia, Hospital Duran i Reynals, IDIBELL, Univerisitat de Barcelona, Barceloma, Spain
23Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
24University of Leipzig, Leipzig, Germany
Exagamglogene Autotemcel for Severe Sickle Cell Disease
Haydar Frangoul, MD1, Franco Locatelli, MD, PhD2, Akshay Sharma, MBBS3, Monica Bhatia, MD4*, Markus Mapara, MD5, Lyndsay Molinari, MD6, Donna Wall, MD7, Robert I. Liem, MD8, Paul Telfer, MD9*, Ami J. Shah, MD10, Marina Cavazzana, MD, PhD11, Selim Corbacioglu, MD, PhD12*, Damiano Rondelli, MD13*, Roland Meisel, MD14*, Laurence Dedeken, MD15, Stephan Lobitz, MSc16*, Mariane de Montalembert, MD, PhD17, Martin H. Steinberg, MD18, Mark C. Walters, MD19, Laura Bower, MD20*, Suzan Imren, MD20*, Christopher Simard, MD20*, Fengjuan Xuan, PhD20*, Weiyu Zhou, PhD20*, Phuong Khanh Morrow, MD21*, William Hobbs, MD, PhD20 and Stephan Grupp, MD, PhD22
1Sarah Cannon Research Institute at The Children’s Hospital at TriStar Centennial, Nashville, TN
2IRCCS, Ospedale Pediatrico Bambino Gesù Rome, Catholic University of the Sacred Heart, Rome, Italy
3St. Jude Children’s Research Hospital, Memphis, TN
4Department of Pediatrics, Columbia University Irving Medical Center, New York – Presbyterian-Morgan Stanley Children’s Hospital, New York, NY
5Division of Hematology and Oncology, Columbia University, New York, NY
6Sarah Cannon Pediatric Transplant and Cellular Therapy Program at Methodist Children’s Hospital, San Antonio, TX
7SickKids, Toronto, Canada
8Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
9Royal London Hospital, Barts Health NHS Trust, London, United Kingdom
10Center for Definitive and Curative Medicine, Stanford University, Palo Alto, CA
11Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris, Paris, France
12University of Regensburg, Regensburg, Germany
13Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
14Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany
15Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium
16Gemeinschaftsklinikum Mittelrhein, Koblenz, Germany
17Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris-Cité, Paris, France
18Boston University Chobanian & Avedisian School of Medicine, Boston, MA
19UCSF Benioff Children’s Hospital, Oakland, CA
20Vertex Pharmaceuticals, Boston, MA
21CRISPR Therapeutics, Cambridge, MA
22Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Karen Sweiss, PharmD1, Craig C. Hofmeister, MD2, Ghulam Rehman Mohyuddin, MD3, Amandeep Godara, MD4, Brian McClune, DO3, Damiano Rondelli, MD5*, Danny Hadidi, MD5*, David Chan, PharmD6*, Matias Eugenio Sanchez, MD7, Min Hai, PhD Candidiate8*, Mitch A. Phelps, PhD8*, Chukwuemeka Uzoka, MD5 and Douglas Sborov, MD, MS9
1Department of Pharmacy Practice, University of Illinois at Chicago, Hinsdale, IL
2Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA
3Huntsman Cancer Institute, University of Utah, Salt Lake City, UT
4Univ of Utah, Salt Lake City, UT
5Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
6Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, IL
7Division of Hematology and Oncology, University of Illinois at Chicago, Chicago, IL
8The Ohio State University, Columbus, OH
9University of Utah School of Medicine, Salt Lake City, UT
Charlotte B Wagner, PharmD1*, Karen Sweiss, PharmD2, Eric Anto, M.S.1*, Rebecca Gonzalez, PharmD3*, Omar Alexis Castaneda Puglianini, MD4, Ciara Louise L. Freeman, PhD, MSc, FRCPC, MRCP5, Filip Ionescu, MD6, Krina K. Patel, MD, MSc7, Christopher Ferreri, MD8*, Mahmoud Gaballa, MD9, Leyla Shune, MD10, Joseph P McGuirk, DO11, Surbhi Sidana, MD12, Vanna Hovanky, MS12*, Jack Khouri, MD13, Danai Dima, MD14, Hamza Hashmi, MD15*, James A Davis, PharmD16*, Aimaz Afrough, MD17, Gurbakhash Kaur, MD, MA18, Larry D. Anderson Jr., MD, PhD19, Peter A. Forsberg, MD20*, Megan Herr, PhD21, Doris K. Hansen, MD22, Douglas Sborov, MD, MS1 and Mehmet H. Kocoglu, MD23
1Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT
2Department of Pharmacy Practice, University of Illinois at Chicago, Hinsdale, IL
3Department of Blood and Marrow Transplant and Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
4Department of Blood and Marrow Transplant & Cellular Immunotherapy, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
5H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
6USF/ Moffitt Cancer Center, Tampa, FL
7University of Texas MD Anderson Cancer Center, Houston, TX
8The University of Texas MD Anderson Cancer Center, Houston
9Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX
10University of Kansas Medical Center, Kansas City, KS
11University of Kansas Medical Center, Westwood, KS
12Stanford University, Stanford, CA
13Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
14Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH
15Medical University of South Carolina, Charleston, SC
16Hollings Cancer Center, Medical University of South Carolina, Charleston, SC
17Hematologic Malignancies and Cellular Therapy, University of Texas Southwestern Medical Center, Dallas, TX
18Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX
19Hematologic Malignancies and Cellular Therapy, UT Southwestern Medical Center, Dallas, TX
20Division of Hematology, University of Colorado Health Blood Disorders and Cell Therapies Center, Aurora, CO
21Roswell Park Comprehensive Cancer Center, Buffalo, NY
22Department of Blood and Marrow Transplantation and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, FL
23University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD
Maureen Okam Achebe, MD, MPH1, Hoda MA Hassab, MD2*, Salam Al-Kindi3*, Clark Brown, MD, PhD4, Paul Telfer, MD5*, Bart J. Biemond6, Thokozeni Lipato7*, Mark Davis8*, Sarah Gray8* and Victor R. Gordeuk, MD9
1Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
2Alexandria University, Alexandria, Egypt
3Sultan Qaboos University, Muscat, Oman
4Pfizer Inc, Norcross, GA
5Royal London Hospital, Barts Health NHS Trust, London, United Kingdom
6Department of Hematology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, Netherlands
7Virginia Commonwealth University Medical Center, Richmond, VA
8Pfizer Inc., South San Francisco, CA
9Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
Guohui Ren, MD, PhD1*, Jiwang Chen, PhD2*, Richard Minshall, PhD2*, Maricela Castellon, MS3*, Maria Armila Ruiz, MS4*, Victor R. Gordeuk, MD5 and Santosh L. Saraf, MD6
1University of Illinois At Chicago, CHICAGO, IL
2University of Illinois at Chicago, Chicago, IL
3University of Illinois at Chicago, Chicago
4University of Illinois At Chicago, Chicago, IL
5Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
6Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
Rita V Masese, MD, MSc1*, Lauren Siewny, MD2*, Siera Gollan, PhD3*, Jeffrey A. Glassberg, MD4, Victor R. Gordeuk, MD5, Jane S Hankins, MD, MS6, Cathy Melvin, PhD, MPH7*, Liliana Preiss8*, Paula Jean Tanabe, PhD, RN, FAEN, FAAN9, Marsha Treadwell, PhD10 and Allison A. King, MD, PhD, MPH11
1School of Nursing, Duke University, Durham, NC
2Department of Emergency Medicine, Duke University Hospital, Durham, NC
3Center for Blood Disorders, Medical College of Georgia, Augusta, GA
4Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
5Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
6St. Jude Children’s Research Hospital, Memphis, TN
7Department of Public Health Sciences, Division of Health Behavior and Health Promotion, Medical University of South Carolina, Charleston, SC
8RTI International, Durham, NC
9Duke University, Durham, NC
10Department of Pediatrics, Division of Hematology, University of California San Francisco Benioff Children’s Hospital, Oakland, CA
11School of Medicine, Washington University, Saint Louis, MO
The Impact of Air Pollutants on a Chicagoland Cohort of Patients with Acute Myeloid Leukemia
Andrew Palmer, BS1*, Garth Rauscher2*, Ivy Abraham, MD3*, Madelyn Burkart, MD4, Ami Dave, MD5*, Nepheli Raptis, MA, BA6, Ahmed Aleem, MD7*, Vedavyas Gannamani, MD8, Amani Erra, MD8*, Sarah Monick, MD9*, Carlos Galvez, MD10, Melissa L. Larson, MD11, Maryam Zia, MD12, Stephanie B. Tsai, MD, MS13, Jessica K. Altman, MD14, Wendy Stock, MD15, Irum Khan, MD4 and Anand Ashwin Patel, MD16
1University of Chicago Pritzker School of Medicine, Chicago, IL
2University of Illinois At Chicago School of Public Health, Chicago, IL
3UChicago Medicine, Chicago, IL
4Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL
5Division of Hematology, Oncology and Stem Cell Transplant, Rush University, Chicago
6Loyola University Stritch School of Medicine, Maywood, IL
7Division of Hematology and Oncology, Loyola University Medical Center, Maywood, IL
8Division of Hematology and Oncology, John H. Stroger Jr. Hospital of Cook County, Chicago, IL
9Department of Medicine, University of Chicago, Chicago, IL
10Division of Hematology/Oncology, University of Illinois at Chicago, Chicago, IL
11Division of Hematology, Oncology and Stem Cell Transplant, Rush University Medical Center, Chicago, IL
12Division of Hematology and Oncology, John H. Stroger Hospital of Cook County, Chicago, IL
13Loyola University Medical Center, Maywood, IL
14Department of Medicine, Division of Hematology/Oncology and the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Northwestern University Feinberg School of Medicine, Chicago, IL
15The University of Chicago Medical Center, Chicago, IL
16Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL
Program: Oral and Poster Abstracts
Session: 506. Bone Marrow Microenvironment: Poster I
Hematology Disease Topics & Pathways:
Research, Translational Research, hematopoiesis, Biological Processes
Saturday, December 9, 2023, 5:30 PM-7:30 PM
Anna M Di Staulo1*, Charles E Ayemoba1*, Aydolun Petenkaya2*, Sen Zhang, PhD1*, Maria Maryanovich, PhD3*, Konstantinos Chronis, PhD2* and Sandra Pinho, PhD1
1Department of Pharmacology & Regenerative Medicine, University of Illinois at Chicago, Chicago, IL
2Department of Biochemistry & Molecular Genetics, University of Illinois at Chicago, Chicago, IL
3Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY
Christina M Abrams, MD1, Natalia Davila2*, Cathy Melvin, PhD, MPH3*, Sherif M. Badawy, MD, MBA, MS4, Michael B Potter, MD5*, Robert Gibson, PhD, MS6*, Allison A King, MD, MPH, PhD7,8, Victor R. Gordeuk, MD9, Chinonyelum Nwosu, MPH10*, Jerlym S. Porter, PhD, MPH11, Sophie Li12*, Jeffrey A. Glassberg, MD13, Richard Lottenberg, MD14, Lisa Klesges, PhD, MS15*, Nirmish Shah, MD16 and Jane S Hankins, MD, MS17,18
1Department of Pediatrics, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC
2College of Nursing, Medical University of South Carolina, Charleston
3Department of Public Health Sciences, Division of Health Behavior and Health Promotion, Medical University of South Carolina, Charleston, SC
4Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University, Chicago, IL
5University of California San Francisco School of Medicine, San Francisco, CA
6Department of Emergency Medicine, Medical College of Georgia-Augusta University, Augusta, GA
7Department of Pediatrics, Washington University in St. Louis, Saint Louis, MO
8Division of Public Health Services, Department of Surgery, Washington University School of Medicine in St. Louis, Saint Louis, MO
9Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
10Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
11Department of Psychology and Biobehavioral Sciences, St. Jude Children’s Research Hospital, Memphis, TN
12RTI International, Research Triangle Park, NC
13Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY
14Department of Medicine, University of Florida, Gainesville, FL
15Department of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St Louis, MO
16Division of Hematology–Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC
17Departments of Hematology and Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN
18Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN
High Grade B-Cell Lymphoma with 11q Aberration Is Not a Rare Event in HIV-Associated Lymphomahttps://ash.confex.com/ash/2023/webprogram/Paper190635.html
Amy Chadburn, MD1, Paul Rubinstein, MD2*, Ethel Cesarman, MD, PhD3, Swarna Gogineni4*, MIn Yang5*, Maneeza Bilal, MS6*, Nadine Demko, MD, CM, MSc7*, Ivo N. Sah Bander, MD, PhD7*, Chandler Sy, MD, PhD7*, Victoria Alagiozian-Angelova, MD8* and Liming Bao, MD, PhD9
1Northwestern School Feinberg School of Medicine Northwester Memorial Hospital, New York, NY
2Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL
3Weill Cornell Medicine, New York
4New York Presbyterian Hospital, New York, NY
5Pathology and Laboratory Medicine, New York Presbyterian Hospital, New York, NY
6Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
7Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
8Pathology and Laboratory Medicine, John H. Stroger Hospital of Cook County, Chicago, IL
9Department ot Pathology, Weill Cornell Medicine, New York, NY
Assessing Pain Severity in Sickle Cell Disease Using Animations and a Graphical Body Image
Julia A. O’Brien, PhD, RN1*, Charles R. Jonassaint, PhD, MHS2, Christina M. Lalama, MS2*, Sherif M. Badawy, MD, MBA, MS3, Megan E. Hamm, PhD2*, Jennifer Stinson, PhD, CPNP, RN4*, Chitra Lalloo, PhD5,6*, Christopher Patrick Carroll, MD7*, Santosh L. Saraf, MD8, Victor R. Gordeuk, MD9,10, Robert Cronin, MD, MS11, Nirmish Shah, MD12, Sophie Lanzkron, MD13, Darla K. Liles, MD14, Leshana Saint-Jean, PhD15*, Michael R. DeBaun, MD, MPH16, Cassandra Trimnell, BA17*, Lakiea Bailey, PhD18*, Raymona Holloway Lawrence, PhD, MPH19*, Laura M. Decastro, MD2, Tonya Palermo, PhD20* and Kaleab Abebe, PhD2*
1School of Nursing, University of Pittsburgh, Pittsburgh, PA
2Department of Medicine, University of Pittsburgh, Pittsburgh, PA
3Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL
4Child Health Evaluative Sciences in Research Institute, Hospital For Sick Children, Toronto, ON, CAN
5Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada
6Child Health Evaluation Sciences, Hospital for Sick Children, Toronto, Canada
7School of Medicine, Johns Hopkins University, Baltimore, MD
8Department of Medicine, University of Illinois College of Medicine, Willowbrook, IL
9Department of Medicine, University of Illinois Chicago, Chicago, IL
10Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
11Department of Internal Medicine, The Ohio State University, Columbus, OH
12Department of Medicine, Division of Hematology – Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC
13Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
14Division of Hematology–Oncology, Department of Internal Medicine, East Carolina University Brody School of Medicine, Greenville, NC
15Vanderbilt University, Nashville, TN
16Vanderbilt University School of Medicine, Nashville, TN
17Sickle Cell 101, San Francisco, CA
18Sickle Cell Community Consortium, Atlanta, GA
19Jiann Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA
20Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA
Kimberly Davidow, MD1, Robin E. Miller, MD2, Shannon Phillips, PhD, RN3*, Alyssa M. Schlenz, PhD4,5*, Martina Mueller, PhD3,6*, Monica L. Hulbert, MD7, Lewis L Hsu, MD, PhD8, Neha Bhasin, MD9, Robert J. Adams, MD, MS10* and Julie Kanter, MD11
1Nemours Center for Cancer and Blood Disorders, Nemours Children’s Hospital – Delaware, Philadelphia, PA
2Nemours Center for Cancer and Blood Disorders, Nemours Children’s Health, Wilmington, DE
3College of Nursing, Medical University of South Carolina, Charleston, SC
4Department of Pediatrics, Medical University of South Carolina, Charleston, SC
5Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO
6Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC
7Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO
8Sickle Cell Center / Pediatric Hematology-Oncology, University of Illinois at Chicago, Chicago, IL
9Department of Pediatrics, Division of Hematology, University of California San Francisco Benioff Children’s Hospital, Oakland, CA
10Department of Neurology, Medical University of South Carolina, Charleston, SC
11Division of Hematology and Oncology, University of Alabama, Birmingham, AL
Charles R. Jonassaint, PhD, MHS1, Christina M. Lalama, MS1*, Julia A. O’Brien, PhD, RN2*, Sherif M. Badawy, MD, MBA, MS3, Megan E. Hamm, PhD1*, Jennifer Stinson, PhD, CPNP, RN4*, Chitra Lalloo, PhD5,6*, Christopher Patrick Carroll, MD7*, Santosh L. Saraf, MD8, Victor R. Gordeuk, MD9, Robert Cronin, MD, MS10, Nirmish Shah, MD11, Sophie M. Lanzkron, MD12, Darla K. Liles, MD13, Leshana Saint-Jean, PhD14*, Michael R. DeBaun, MD, MPH15, Cassandra Trimnell, BA16*, Lakiea Bailey, PhD17*, Raymona Holloway Lawrence, PhD, MPH18*, Laura M. Decastro, MD1, Tonya Palermo, PhD19* and Kaleab Abebe, PhD1*
1Department of Medicine, University of Pittsburgh, Pittsburgh, PA
2School of Nursing, University of Pittsburgh, Pittsburgh, PA
3Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL
4Child Health Evaluative Sciences in Research Institute, Hospital For Sick Children, Toronto, ON, CAN
5Child Health Evaluation Sciences, Hospital for Sick Children, Toronto, Canada
6Institute for Health Policy, Management & Evaluation, University of Toronto, Toronto, Canada
7School of Medicine, Johns Hopkins University, Baltimore, MD
8Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL
9Sickle Cell Center, University of Illinois at Chicago, Chicago, IL
10Department of Internal Medicine, The Ohio State University, Columbus, OH
11Division of Hematology–Duke Sickle Cell Comprehensive Care Unit, Duke University Medical Center, Durham, NC
12Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD
13Division of Hematology–Oncology, Department of Internal Medicine, East Carolina University Brody School of Medicine, Greenville, NC
14Vanderbilt University, Nashville, TN
15Vanderbilt University School of Medicine, Nashville, TN
16Sickle Cell 101, San Francisco, CA
17Sickle Cell Community Consortium, Atlanta, GA
18Jiann Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA
19Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA
Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia
Franco Locatelli, MD, PhD1, Peter Lang, MD, PhD2*, Selim Corbacioglu, MD, PhD3*, Donna Wall, MD4, Roland Meisel, MD5*, Amanda M Li, MD6, Josu de La Fuente, PhD7, Ami J. Shah, MD8, Ben Carpenter, MD, PhD9*, Janet L. Kwiatkowski, MD, MSCE10, Markus Mapara, MD11, Robert I. Liem, MD12, Maria Domenica Cappellini, MD13, Mattia Algeri, MD1*, Antonis Kattamis, MD, PhD14, Sujit Sheth, MD15, Stephan Grupp, MD, PhD16, Puja Kohli, MD, MMSc17*, Daoyuan Shi, PhD17*, Leorah Ross, MD, PhD17*, Yael Bobruff, PhD17*, Christopher Simard, MD17*, Lanju Zhang, PhD17*, Phuong Khanh Morrow, MD18*, William Hobbs, MD, PhD17 and Haydar Frangoul, MD19
1IRCCS, Ospedale Pediatrico Bambino Gesù Rome, Catholic University of the Sacred Heart, Rome, Italy
2University of Tübingen, Tübingen, Germany
3University of Regensburg, Regensburg, Germany
4The Hospital for Sick Children/University of Toronto, Toronto, Canada
5Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany
6BC Children’s Hospital, University of British Columbia, Vancouver, Canada
7Imperial College Healthcare NHS Trust, St Mary’s Hospital, London, United Kingdom
8Center for Definitive and Curative Medicine, Stanford University, Palo Alto, CA
9University College London Hospitals NHS Foundation Trust, London, United Kingdom
10Children’s Hospital of Philadelphia and Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA
11Division of Hematology and Oncology, Columbia University, New York, NY
12Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
13University of Milan, Milan, Italy
14National and Kapodistrian University of Athens, Athens, Greece
15Joan and Sanford I Weill Medical College of Cornell University, New York, NY
16Children’s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
17Vertex Pharmaceuticals, Boston, MA
18CRISPR Therapeutics, Cambridge, MA
Impact of Acute Exercise Challenge on Airway Dynamics in Children and Young Adults with Sickle Cell Anemiahttps://ash.confex.com/ash/2023/webprogram/Paper182904.html
Robyn T. Cohen, MD, MPH1*, Jane S Hankins, MD, MS2, Kirsten K Ness, PhD3*, Lewis L Hsu, MD, PhD4, Tracy Baynard, PhD5*, Amy Tang, MD6, Shlomit Radom-Aizik, PhD7*, Kevin Guerrero8*, Mark Rodeghier, PhD9* and Robert I. Liem, MD10
1Department of Pediatrics, Boston Medical Center, Boston, MA
2Departments of Hematology and Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, TN
3St. Jude Children’s Research Hospital, Memphis, TN
4Sickle Cell Center / Pediatric Hematology-Oncology, University of Illinois at Chicago, Chicago, IL
5University of Massachusetts Boston, Boston, MA
6Aflac Cancer & Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA
7University of California, Irvine, Irvine, CA
8Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
9Rodeghier Consultants, Chicago, IL
10Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL
Notch Signaling Is Required for Extramedullary Hematopoiesis in the Adult Liver
Thilinie Bandara*, Lijian Shao, MD, PhD*, Na Yoon Paik*, Jacob Neethling, Paulina Rodriguez* and Kostandin V Pajcini, PhD
Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL