Akt promising target for cancer treatment, but which one?

Akt is one of the most frequently stimulated oncoprotein in human cancers and whose activation often elicits chemoresistance, making it a promising target for treatment. However, there are three Akt isoforms, and it is unclear which one of them, either individually or in combination, could be inhibited systemically for cancer therapy without severe adverse consequences. Akt, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway that regulates…

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Navigators overcoming barriers to lessen disparity gap in breast cancer patients

The large disparity gap between Black and white women undergoing breast cancer screening can be reduced through better education, support and care coordination provided by patient navigators, according to new research conducted at the University of Illinois Cancer Center. Patient navigators – individuals who help guide a patient through the healthcare system, including screening, diagnosis, treatment and follow-up – are a critical component of an integrated healthcare team approach where they can expand…

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Sun developing new strategy to prevent, treat colon cancer

University of Illinois at Chicago researcher Jun Sun is developing a new strategy to restore host-microbe relationships that can potentially prevent and treat colon cancer.The gut microbiome, a newly discovered “organ” that aids in the body’s digestion of food, metabolism, immune function and brain health, plays a critical role in the maturation and continued education of the host immune response, said Sun, PhD, AGAF, FAPS, professor of gastroenterology and hepatology at the University…

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Community-to-bench model is wave of the future

Share on facebook Facebook Share on twitter Twitter Out with the old – “bench to bedside” – and in with the new – “community-to-bench.”In a new commentary published in the journal EBioMedicine, Kathy Tossas, PhD, MS, co-director of the Office of Community Engaged Research and Implementation Science at the University of Illinois Cancer Center, writes that a “community to bench” model, such as that employed at the UI Cancer Center championed by former…

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New paper shows differences in location

University of Illinois Cancer Center member Greg Calip served as co-author on a new study that showed regional differences in improved survival of patients with de novo metastatic breast cancer over time. The work was published in the journal Cancer. Calip, PharmD, MPH, PhD, and his colleagues studied patients in the Surveillance, Epidemiology, and End Results (SEER) 9 population and an institutional cohort with de novo metastatic breast cancer (MBC), which is a…

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Single cell sequencing sheds light on why cancers form in specific cell types

University of Illinois Cancer Center member Maxim Frolov, PhD, and his graduate student, Majd Ariss, have developed a single-cell sequencing instrument to isolate cells of the eye in developing fruit flies, which the lab uses as a model system to study gene expression changes caused by mutations in the retinoblastoma tumor gene. The study’s findings have been published in Nature Communications. Retinoblastoma is an eye cancer that begins in the retina. It is…

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New research explores policies on timely breast cancer diagnosis for underserved women

Richard Warnecke knows that disparities exist between minority and white women receiving a timely breast cancer diagnosis. The question he has is why. In a new paper published online in the journal Cancer Epidemiology, Biomarkers & Prevention, Warnecke, PhD, University of Illinois Cancer Center member and professor emeritus of epidemiology, public administration and sociology, reviewed data from more than 900 black, Latina and white patients to learn about the barriers they encounter to…

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