Dr. Pavel Petukhov is a Professor of Medicinal Chemistry and Pharmacognosy at the University of Illinois at Chicago. He has a broad background in medicinal chemistry, synthetic chemistry, chemical biology, and computer-aided drug design.
Dr. Petukhov received extensive training in synthetic organic chemistry, medicinal chemistry, and computer-aided drug design during his PhD and postdoctoral research. As PI, co-PI, and co-investigator on several previous NIH and DoD-funded grants, he had gained broad experience in design and administration of complex multidisciplinary grants geared toward medicinal chemistry, in silico screening, computer-aided design, chemical biology, design and discovery of novel small molecules as chemical tools to study biology, and discovery and development of novel small molecule-based therapeutic approaches to a variety of diseases and conditions.
His current research interests include development of novel small molecule modulators of epigenetic machinery, specifically for histone deacetylases (HDAC), development of novel chemical tools to study epigenetic machinery, discovery of novel inhibitors of hepatitis B replication, hit-to-lead computer-aided molecular design and medicinal chemistry studies toward development of therapeutics for schistosomiasis, and discovery of novel small molecules inhibitors of cystathionine gamma lyase as therapeutics for sleep apnea.
Over the years, he has supervised 12 postdocs, 19 graduate students, 6 undergraduate students. As PI and co-PI, Dr. Petukhov successfully administered the projects (e.g. staffing, research coordination, budget, MPI interactions), collaborated with other researchers, and produced several peer-reviewed publications from each project.