Research by University of Illinois Cancer Center members, trainees and co-authors was featured at the recent AACR Annual Meeting in Orlando, Florida. Details below.
Session LBPO.ET01 – Late-Breaking Research: Experimental and Molecular Therapeutics 1
LB009 / 1 – Notch4 inhibition by a novel neutralizing antibody reduces tumor progression and increases macrophage recruitment within the tumor microenvironment
Authors: Jason W. L. Eng, L.A. Naiche, Bhairavi Swaminathan, Yu Kato, Krishna Thakkar, Katherine Ann Alexander, Rahul Vadakath, James H. Herts, Rajyasree Emmadi, Junji Matsui, Jan K. Kitajewski.
Session PO.COVID01.01 – COVID-19 and Cancer
793 / 2 – Mechanism of interferon induction by cannabidiol (CBD) and analogues in lung cancer cells
Authors: Leticia Stock, Lydia Robinson-Mailman, Long C. Nguyen, Shao-Nong Chen, Guido F. Pauli, Marsha R. Rosner
Session PO.ET01.01 – Oncogenes and Tumor Suppressor Genes as Targets for Therapy 1
536 / 3 – The role of CCN1 in mutant K-RAS addiction in pancreatic ductal adenocarcinoma
Authors: Archana De, Vijayalaxmi Gupta, Amlan Das, Arnab Ghosh, Inamul Haque, Laster Lau, Sushanta K. Banerjee, Snigdha Banerjee
Session PO.TB04.02 – Regulation of Invasion and Migration
3618 / 24 – The role of endothelial ACKR1 in triple-negative breast cancer metastasis
Authors: Samuel Tanner Roach, Chinwe Ewenighi-Amankwah, J. Dufraine, L.A. Naiche, Jan K. Kitajewski
Session PO.CL01.05 – Biomarkers of Therapeutic Benefit 5
5460 / 10 – Novel immunohistochemistry-based predictive and prognostic tests for hormone receptor-positive breast cancer
Authors: Danira Jaksic, Amandeep Kaur, Dean Reddick, David David Datzkiw, Shailly Varma Shrivastav, Vijayakrishna Gadi, Leigh Murphy, Anuraag Shrivastav
Session LBPO.ET02 – Late-Breaking Research: Experimental and Molecular Therapeutics 2
LB231 / 6 – Overcoming KRAS G12C inhibitor resistance with a chaperone-mediated protein degrader (CHAMP)
Authors: Ines Pulido Endrino, Qiyue Luan, Jennifer Graeber, Brianna Borger, Chenghao Ying, Jinhua Li, Zimo Yang, Zhiyong Wang, Yaya Wang, Yuetong Sun, Yan Dai, Ian Papautsky, Thomas L. Prince, Guoqiang Wang, Kevin P. Foley, Weiwen Ying, Takeshi Shimamura.
Session PO.CL01.17 – Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 4
5598 / 22 – Microfluidic isolation and capture of circulating tumor cells and clusters from mouse blood
Authors: Celine Macaraniag, Jian Zhou, Ian Papautsky, Jing Li, William Putzbach, Nissim Hay
Session PO.TB01.01 – Advances in Angiogenesis
4605 / 23 – Chronic VEGF-C signaling exacerbates the progression of non-alcoholic steatohepatitis and hepatocarcinoma through endothelial VEGFR2 and VEGFR
Authors: Seock-Won Youn, Jason W.-L. Eng, Bhairavi Swaminathan, Pamela Teneqexhi, Rahul Vadakath, Jan K. Kitajewski
Session PO.TB11.05 – Single Cell and Spatial Considerations of the Tumor Microenvironment
4707 / 20 – LED photobleaching-based multiplex 3D microscopy of the tumor microenvironment
Authors: Jingtian Zheng, Evan Phillips, Yi-Chien Wu, Steve Seung-Young Lee, Vytautas Bindokas
Session PO.IM01.15 – Combination Immunotherapies 1
5078 / 12 – Immune response markers following combination treatment with oncolytic adenovirus AMUN-003 and immune checkpoint inhibitors in a murine model of triple negative breast cancer
Authors: Soon Cheon Shin, Beniamin Filimon, Yuefeng Yang, Zebin Hu, Vijayakrishna K Gadi, Weidong Xu