Research by University of Illinois Cancer Center members, trainees, co-authors and others at the University of Illinois Chicago will be featured at the American Association for Cancer Research (AACR) 2024 Annual Meeting to be held April 5-10 in San Diego, California. A list of the abstracts is below.
Christen Sandoval1, Eliza Brumer Cohn2, Leslie R. Carnahan3, Vida Henderson2, Tigist Mersha1, Neha Hippalgaonkar4, Joe Horowitz5, Sarah Khan6, Kauthar Salum2, Ana Williams3, Lolita Coleman7, Beluah Brent7, Anne Marie Murphy1, Paris Thomas8, Paramjeet Khosla6, Kent Hoskins3, Ryan Nguyen3
1School of Public Health, University of Illinois Chicago, Chicago, IL,2Fred Hutch Cancer Center, Seattle, WA,3University of Illinois Cancer Center, Chicago, IL,4Division of Hematology/Oncology, University of Illinois Chicago, Chicago, IL,5College of Medicine, University of Illinois Chicago, Chicago, IL,6Sinai Chicago, Chicago, IL,7Sisters Working It Out, Chicago, IL,8Equal Hope, Chicago, IL
G. Goba1, J. Sun1, Q. Class1, J. Schwartz1, S. Kim1, K. Watson1, L. Tussing-Hummphreys1, Y. Molina1, S. MacLaughlan1, Z. Xu1, B. Aldred1, S. K. Kolar Rajanna1, T. Alexander1, A.-B. Moscicki2;
1University of Illinois Cancer Center, Chicago, IL, 2University of California, Los Angeles, Los Angles, CA
N. Hippalgaonkar1, M. Weinfeld1, C. Weldon2, J. Trosman2, C. Chan3, S. Khan4, S. Paduri4, V. Reddy4, A. Sakhuja4, P. Khosla4, M. Pasquinelli1, L. Feldman1;
1University of Illinois at Chicago, Chicago, IL, 2Center for Business Models in Healthcare, Glencoe, IL, 3Jesse Brown VA Medical Center, Chicago, IL, 4Sinai Chicago, Chicago, IL
1496 / 9 – The role of endothelial ACKR1 in breast cancer metastasis
S. T. Roach, R. Patel, S. Thomas, C. Ewenighi-Amankwah, J. Dufraine, L. A. Naiche, J. Kitajewski;
University of Illinois at Chicago, Chicago, IL
V. Bakthavachalam, M. Madhayan, M. Sanborn, J. Rehman, P. Bellur;
University of Illinois at Chicago, Chicago, IL
2770 / 28 – A novel MIRO2/MYO9B/RhoA signaling axis controls tumor cell invasion and metastasis
D. P. Boulton1, C. J. Hughes1, V. Vaira2, A. Jindal3, M. Raza1, S. Purdy1, S. Sant4, H. L. Ford1, M. Caino1;
1University of Colorado Anschutz Medical Campus, Aurora, CO, 2Università degli Studi di Milano, Milan, Italy, 3University of Pittsburgh, Pittsburgh, PA, 4University of Illinois Chicago, Chicago, IL
N. Hippalgaonkar1, K. Drabek1, A. Aseem1, T. Maga1, L. Balay1, V. Pan1, P. Ganschow2, K. Tawagi1, N. Awati1, N. Reizine1;
1University of Illinois at Chicago, Chicago, IL, 2University of Illinois Cancer Center, Chicago, IL
A. Shrivastav1, D. Reddick1, A. Meher1, S. Varma Shrivastav2, S. Mittal1, V. K. Gadi3, L. Murphy4;
1The University of Winnipeg, Winnipeg, MB, Canada, 2Oncodrex Inc., Winnipeg, MB, Canada, 3University of Illinois Cancer Center, Chicago, IL, 4CancerCare Manitoba, Winnipeg, MB, Canada
S. Thomas1, Y. K. Hong2, Y. Samhouri3, J. Larkin4, D. J. Olson5, G. K. In6, V. Atkinson7, P. Lammers8, A. J. S. Furness4, J. Martin-Liberal9, P. Terheyden10, A. S. Poklepovic11, R. H. Nguyen12, I. Peretz13, M. Butler14, A. Khattak15, L. Spain16, E. Gaughan17, M. Wilson18, J. W. Dubay19, A. Williams20, S. Goff21, G. C. Doolittle22, J. Chesney23, F. Finckenstein24, J. Chou24, X. Wu24, G. Sulur24, W. Shi24, J. Haanen25;
1Orlando Health, Orlando, FL, 2Cooper University Hospital, Camden, NJ, 3Allegheny Health Network Cancer Institute, Pittsburgh, PA, 4The Royal Marsden NHS Foundation Trust, London, United Kingdom, 5University of Chicago, Chicago, IL, 6University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA, 7Greenslopes Private Hospital, Greenslopes, Queensland, Australia, 8Baptist Cancer Center, Memphis, TN, 9ICO L’Hospitalet – Hospital Duran i Reynals, Barcelona, Spain, 10University of Lübeck, Lübeck, Germany, 11Virginia Commonwealth University, Richmond, VA, 12University of Illinois Hospital & Health Sciences System, Chicago, IL, 13Rabin Medical Center – PPDS, Beilinson, Israel, 14Princess Margaret Cancer Centre, Toronto, ON, Canada, 15Fiona Stanley Hospital & Edith Cowan University, Murdoch & Joondalup, Australia, 16Peter McCallum Cancer Centre, Melbourne, Australia, 17University of Virginia, Charlottesville, VA, 18St. Luke’s University Health Network, Division of Hematology Medical Oncology, Easton, PA, 19University of Alabama at Birmingham, O’Neal Comprehensive Cancer Center, Birmingham, AL, 20Sarah Cannon Research Institute SCRI, London, United Kingdom, 21National Cancer Institute, Bethesda, MD, 22University of Kansas Medical Center, Kansas City, KS, 23UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, 24Iovance Biotherapeutics Inc, San Carlos, CA, 25Netherlands Cancer Institute & Leiden University Medical Center, Amsterdam & Leiden, Netherlands
6121 / 15 – Racial differences in the intratumoral immune cell infiltrate in luminal breast cancer
N. Hippalgaonkar1, G. Chlipala1, D. Huo2, G. Rauscher1, N. Adler1, J. Kitajewski1, K. Hoskins1;
1University of Illinois at Chicago, Chicago, IL, 2University of Chicago, Chicago, IL
6608 – Therapeutic enzyme depletion of L-serine for the treatment of serine auxotrophic tumors
Vipin Rawat1, Huiping Zhao1, Ladan Mashouri2, Prarthana Prasanth1, Kelly Conger1, Sarita Bhetawal2, Alessandra Araujo2, Everett Stone2, Jonathan Coloff1
1Physiology and Biophysics, University of Illinois College of Med. at Chicago, Chicago, IL,2University of Texas at Austin, Austin, TX
D. Principe1, M. Pasquinelli1, R. Nguyen1, L. Feldman1, A. Aissa2, F. D. Weinberg1;
1University of Illinois Chicago, Chicago, IL, 2Federal University of São Paulo, Sao Paulo, Brazil
7485 / 1 – Microfluidic detection of dual positive cells in whole blood of metastatic breast cancer patients J. Zhou, Q. Luan, C. Macaraniag, A. B. Guzman, M. Mantice, O. Danciu, K. F. Hoskins, I. Papautsky;
University of Illinois at Chicago, Chicago, IL
H. Dai1, P. G. Wolf2, L. Tussing-Humphreys3, E. Mutlu3, J. M. Ridlon1, R. Gaskins1;
1University of Illinois at Urbana-Champaign, Urbana, IL, 2Purdue University, West Lafayette, IN, 3University of Illinois at Chicago, Chicago, IL
Mariana Bustamante Eduardo1, Gannon Cottone1, Shiyu Liu2, Flavio R. Palma1, Maria Paula Zappia3, Abul B.M.M.K. Islam3, Elizaveta V. Benevolenskaya3, Maxim V. Frolov3, Jason Locasale2, Marcelo G. Bonini1, Navdeep S. Chandel1, Seema Khan1, Susan Clare1
1Northwestern Univ. Feinberg School of Medicine, Chicago, IL,2Duke University, Durham, NC,3University of Illinois at Chicago, Chicago, IL
A. Roy1, M. Davis1, S. Weinberg2, A. Mallisetty1, A. Hulbert1, F. D. Weinberg1;
1University of Illinois Chicago, Chicago, IL, 2Northwestern University, Chicago, IL
L. Lonini1, S. Khare1, T. D. Lopez1, S. Szydlo1, M. Streit1, O. A. Karginova1, M. K. Flaherty1, A. Salahudeen2, A. Kunert3, A. Oja3, K. Sasser1, M. C. Stumpe1, C.-S. Ho1;
1Tempus Labs, Chicago, IL, 2University of Illinois Chicago, Chicago, IL, 3Sanofi, Amsterdam, Netherlands
6280 / 19 – Vitamin D enhances luminal differentiation of prostate organoids more than androgens
O. F. Cerna, Jr., L. Nonn, M. Schlicht, K. Krieger;
University of Illinois at Chicago, Chicago, IL
7649 / 10 – Inflammatory biomarkers by sarcopenia status in diverse individuals with lung cancer
C. A. Byrne1, G. Fantuzzi1, V. M. Oddo1, S. Kim1, T. J. Koh1, S. L. Gomez2;
1University of Illinois at Chicago, Chicago, IL, 2Rush University, Chicago, IL
7495 / 11 – Validation of microfluidic isolation of circulating pancreatic tumor cells from blood
C. Macaraniag, I. Khan, J. Zhou, P. C. Giulianotti, A. Borgeat, G. Votta-Velis, I. Papautsky;
University of Illinois at Chicago, Chicago, IL
3323 / 11 – Novel Pan-RAS inhibitor ADT-007: A unique mechanism of antitumor selectivity in pancreatic and colorectal carcinoma models J. Wang1, A. B. Keeton1, S. Ramesh1, P. Johnson1, Y. Y. Maxuitenko1, J. B. Foote2, C.-H. Huang1, K. L. Berry1, K. Fadlalla1, B. D. S. Reddy2, G. P. Nagaraju2, E. Nurmemmedov3, I. Babic3, V. Gaponenko4, X. Chen1, B. F. El-Rayes2, D. J. Buchsbaum2, G. A. Piazza1;
1Auburn University Harrison College of Pharmacy, Auburn, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Nerd Bio, San Diego, CA, 4University of Illinois Chicago, Chicago, IL
76 / 12 – Correlated multi-scale 3D optical microscopy of tumor tissues J. Zheng, S.-Y. Lee;
University of Illinois at Chicago, Chicago, IL
Q. Luan, I. Pulido, A. Isagirre, J. Zhou, T. Shimamura, I. Papautsky;
University of Illinois Chicago, Chicago, IL
S. V. Bendre1, N. Krawczynska1, S. Bhogale1, E. Weisser1, S. Han1, B. Hajyousif1, A. Singh1, R. K C1, Y. Wang1, C. P. Schane1, A. T. Nelczyk1, A. DasGupta1, H. E. V. Gamage1, K. T. VanBortle1, E. Tajkhorshid1, S. Sinha2, W. Cho3, E. R. Nelson1;
1University of Illinois at Urbana-Champaign, Urbana, IL, 2Georgia Institue of Technology, Atlanta, GA, 3University of Illinois Chicago, Chicago, IL
I. Pulido Endrino1, L. gunder1, Q. Luan1, C. Ying2, Z. Yang2, J. Li2, Y. Wang2, Y. Sun2, C. Liu2, Y. Dai2, H. Zhou2, M. Massad1, I. Papautsky1, T. L. Prince3, G. Wang2, K. P. Foley3, W. Ying2;
1University of Illinois Chicago, Chicago, IL, 2RANOK Therapeutics, Hangzhou, China, 3RANOK Therapeutics, Waltham, MA
3771 / 27 – 3D correlated multi-scale cellular and molecular architecture of solid tumors
S.-Y. Lee1, Y.-C. Wu1, J. Zheng1, E. Khalil1, S. Wang2, A. Lippert3, J. Plank3;
1University of Illinois at Chicago, Chicago, IL, 2University of Chicago, Chicago, IL, 3Southern Methodist University, Dallas, TX
3772 / 28 – Tissue-niche-based and cell-type-selective in-depth proteomics
Y.-C. Wu1, E. Abi Khalil1, S. Weng2, S. Lee1;
1University of Illinois at Chicago, Chicago, IL, 2University of Chicago, Chicago, IL
4978 / 14 – Genomic characterization of metastatic pancreatic cancer according to tumor sample sites
S. Y. Goksu1, M. Ozer2, B. Bacik Goksu3, N. N. Sanford4, A. Jones4, N. Verma4, S. Kazmi4;
1West Suburban Medical Center, Oak Park, IL, 2Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 3University of Illinois at Chicago, Chicago, IL, 4UT Southwestern Medical Center, Dallas, TX
M. Ozer1, S. Y. Goksu2, B. Bacik Goksu3, N. N. Sanford4, A. Jones4, N. Verma4, S. Kazmi4;
1Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, 2West Suburban Medical Center, Oak Park, IL, 3University of Illinois at Chicago, Chicago, IL, 4UT Southwestern Medical Center, Dallas, TX
5740 / 8 – Peptide-functionalized dendrimers for enhanced binding to immune checkpoint proteins
P. A. Rawding1, F. Coppola2, D. Kim1, M. Poellmann1, D. Wheeler1, P. Král2, S. Hong1;
1University of Wisconsin-Madison, Madison, WI, 2University of Illinois at Chicago, Chicago, IL
H. Heath1, J. Yoo1, V. Sharma1, H. McGee1, A. Soliman1, A. Mohamed2, A. K. Matthews3, R. Winn4, Z. Madak-Erdogan1, S. Kim5;
1University of Illinois at Urbana-Champaign, Champaign, IL, 2University of Illinois at Chicago, Chicago, IL, 3Columbia University, New York, NY, 4Virginia Commonwealth University, Richmond, VA, 5University of Illinois at Chicago, Champaign, IL
S. R. Noonepalle1, N. Gajendran1, M. Suresh1, X. Li1, M. D. G. Hernandez2, C. Z. Delgado3, N. Aghdam4, M. Berrigen5, T. Knox1, K. Tan1, M. Durr1, E. Sotomayor6, K. B. Chiappinelli2, D. Wardrop7, A. Horvath2, B. A. Shook2, N. H. Lee2, A. Dritschilo1, R. Fernandes2, K. Musunuri8, M. Shibata2, A. Villagra1;
1Georgetown University, Washington DC, DC, 2George Washington University, Washington DC, DC, 3University of Houston, Downtown, Houston, TX, 4Beth Israel Deaconess Medical Center, Boston, MA, 5George Wsahington University, Washington DC, DC, 6Tampa General Hospital, Tampa, FL, 7University of Illinois, Chicago, IL, 8Avstera Therapeutics Inc, Malvern, PA
LB453 / 29 – Distinct mechanism of CXCR7 activation in EGFR-mutated NSCLC by chemokines
L. C. Gunder1, I. Pulido1, J. H. Becker2, M. G. Massad1, T. Shimamura1;
1University of Illinois at Chicago, Chicago, IL, 2Northwestern University, Chicago, IL
7289 / 4 – PancreaAlert: Intelligent nanoengineered biosensor for pancreatic cancer
Meenal Karunanidhi1, Hemalatha Kanniyappan1, Edith Zhan2, Ruth Mathew3, Yani Sun3, Junyi Wu4, Yan Yan4, Gnanasekar Munirathinam1, Mathew T. Mathew1
1University of Illinois College of Medicine (Rockford), Rockford, IL,2Hononegah High School, Rockton, IL,3University of Illinois Chicago, Chicago, IL,4IIT, Chicago, IL
Atieh Hajirahimkhan1, Elizabeth T. Bartom1, Sriram Chandrasekaran2, Ruohui Chen1, Jeremy J. Johnson3, Susan E. Clare1, Seema A. Khan1
1Northwestern University – Chicago, Chicago, IL,2University of Michigan, Ann Arbor, MI,3University of Illinois Chicago, Chicago, IL