Dr. Jonathan Coloff is an Assistant Professor in the Department of Physiology and Biostatistics. His research is focused on breast cancer, metabolic differences between tumor and normal tissues, identifying mechanisms, and cancer therapy. He began studying cancer metabolism as a graduate student in Dr. Jeff Rathmells laboratory at Duke University, where he investigated how the metabolic state of a cell could influence cell fate decisions. Specifically, Dr. Coloff investigated how a highly-glycolytic metabolic phenotype, similar to that observed in tumors, could contribute to the ability of cancer cells in resisting cell death.For his postdoctoral work, he studied cancer metabolism in Dr. Joan Brugges laboratory at Harvard Medical School, using 3D culture to focus on how changes in proliferation impact cellular metabolic activity. In his independent laboratory, he is investigating how rate of proliferation and tumor lineage impact metabolic vulnerabilities.Dr. Coloff is also continuing to develop improved in vitro tissue culture methods that allow comprehensive metabolic characterization using metabolomics and stable isotope tracer methods.His research is focused on breast cancer, metabolic differences between tumor and normal tissues, identifying mechanisms and cancer therapy.