Sandra Pinho, PhD

Sandra Pinho, PhD, is Assistant Professor of Pharmacology in the Department of Pharmacology and Regenerative Medicine at the University of Illinois College of Medicine Chicago. With age, hematopoietic stem cells (HSCs) suffer a decline in their regenerative capacity leading to impaired immune responses and contributing to the development of hematopoietic malignancies such as acute myeloid leukemia (AML), fueled by resilient cancer stem cells. Patient outcomes in AML remain poor, especially among older patients who are the most affected. Since healthy HSCs are tightly linked with their microenvironment for normal function, HSC aging and malignancy may be related to deterioration of the niche. Her research focuses on the regulation of the stem cell microenvironment in aging and in malignancies of the hematopoietic system. The goal is to design novel rejuvenation technologies for aged HSCs and develop strategies that will improve cancer therapy.

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Ong, Pinho in Circulation Research

For some leukemia patients, the only potential chemotherapy option is a drug that also carries a high risk of heart failure. This means that some patients who recover from their […]

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