Dr. Kostandin Pajcini
My research program brings together the highly conserved cell-cell signaling mechanisms to the study of hematopoietic development and disorders. A key area of study is the role of Notch signaling in the interactions of hematopoietic stem cells with the fetal liver and adult bone marrow niches. Because aberrant Notch signaling leads to T-cell acute lymphoblastic leukemia (T-ALL). In my independent research program, we are focusing on how to specifically target hyperactive Notch mutations in T-ALL by identifying novel gene targets and by directly targeting the Notch receptor mutations though gene editing.