Kostandin Pajcini, PhD

Kostandin Pajcini, PhD, is Associate Professor of Pharmacology at the University of Illinois College of Medicine. His research focuses on bringing together the highly conserved cell-cell signaling mechanisms to the study of hematopoietic development and disorders. A key area of his work is the role of Notch signaling in the interactions of hematopoietic stem cells with the fetal liver and adult bone marrow niches because aberrant Notch signaling leads to T-cell acute lymphoblastic leukemia (T-ALL). The focus is on how to specifically target hyperactive Notch mutations in T-ALL by identifying novel gene targets and by directly targeting the Notch receptor mutations though gene editing.

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Notch Signaling Publication by Cancer Center Members

University of Illinois Cancer Center members and leaders are authors of a study published in the journal Cellular and Molecular Life Sciences that investigated Notch signaling in lung vascular endo…

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