Dr. Kenter is a Professor in the Department of Microbiology and Immunology. Her research is focused on immunoglobulin gene rearrangements and the role that Mbd4 has in somatic hypermutation and cancer. Dr. Kenter’s laboratory has been focused on the molecular mechanism of class switch recombination (CSR) for many years. They designed an assay for double strand breaks in S regions and detected these breaks in S regions of B cells induced for CSR.
Her lab discovered transcription factors bound to S region which may modulate isotype specific recombination. More recently, they have examined the chromatin structure of the Igh locus in the context of CSR. These studies have revealed that chromatin accessibility and transcription are linked and that RNA polymerase pausing is intrinsic to these processes. Dr. Kenter’s team developed evidence that the Mbd4 is a critical regulator of CSR. Current studies focus on the role of Mbd4, a uracil glycosylase, in somatic hypermutation and cancer.
Her research is focused on immunoglobulin gene rearrangements and the role that Mbd4 has in somatic hypermutation and cancer.