Search for Clinical Trials

Clinical trials are research studies designed to answer scientific questions and discover better ways to prevent, diagnose or treat various diseases and conditions, including cancer. A clinical trial is one of the final stages of a long and careful cancer research process. Scientists begin by developing and testing new ideas in a laboratory. If an approach seems promising, the next step may be testing a treatment in animals to learn how it affects cancer in a living being, and whether it has harmful effects.

Treatments that work well in the lab or in animals, however, may not always work well in people. When the potential treatment is deemed safe enough to explore its effects on humans, it proceeds to be studied in a clinical trial. In the context of cancer, these trials are performed with cancer patients to learn whether promising treatments are safe and effective.

Clinical trials are divided into four phases:

  • Phase 1 – These studies are to find the same does of a drug, to decide how a potential new treatment should be given, or to see how a potential new treatment affect the human body and fights cancer.
  • Phase 2 – These studies are to determine if a potential new treatment has an effect on a certain cancer and to see how it affects the human body and fights cancer.
  • Phase 3 –Phase III studies compare a new potential treatment with the current standard treatment.
  • Phase 4 – Phase 4 studies study the long-term safety and effectiveness of new treatments.  They take place after the treatment has been approved by the US Food and Drug Administration (FDA) and is on the market.

The most successful cancer treatments today are based on what we have learned from clinical trials. As a result, people with cancer are living longer, with a better quality of life. Participating in clinical trials at the University of Illinois Cancer Center may not only benefit you, but it could also help future patients through the development of newer, safer treatments.

For more information about cancer clinical trials, please see the following resources: National Cancer Institute (NCI), Clinical Trials Information for Patients and CaregiversThe American Cancer Society, Clinical TrialsCancer Support Community, Cancer Clinical TrialsClinicalTrials.gov clinical trials database.

Below is a listing of UI Cancer Center clinical studies currently enrolling participants.  Click on the dropdown menu below to filter the list by the site of your disease.  If you are interested in participating in a trial listed, please email cancertrials@uic.edu or call 312-355-5112.

For more information on the study, click on the ClinicalTrials.gov ID, if available.
For a list of clinical trials nationwide, please see www.ClinicalTrials.gov.

 

Study Title Researcher Adult/Children Sponsor Disease Site ClinicalTrials.gov ID
A031501: Phase III Randomized Adjuvant Study Of MK-3475 (Pembrolizumab) In Muscle Invasive And Locally Advanced Urothelial Carcinoma (Ambassador) Versus ObservationAbern, Michael RyanAdultsAllianceBladder NCT03244384
Arterial Function and the Effect of Acute Aerobic Exercise in Breast Cancer Survivors.Baynard, TracyAdultsUniversity of Illinois at Chicago (UIC)Breast - Female
BTCRC-GI15-015: A Phase II Study of FOLFOX combined with Nab-Paclitaxel (FOLFOX-A) in the Treatment of Metastatic or Advanced Unresectable Gastric, Gastro-Esophageal Junction AdenocarcinomaChowdhery, RozinaAdultsBig Ten Cancer Research ConsortiumEsophagus; Stomach NCT03283761
SWOG S1207: Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk Hormone Receptor-Positive and HER/NEU Negative Breast CancerDanciu, Oana, CAdultsSouthwest Oncology GroupBreast - Female; Breast - Male NCT01674140
NSABP B-55: A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Multi-Centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients with Germline BRCA1/2 Mutations and High Risk HER2 Negative Primary Breast Cancer Who Have Completed Definitive Local Treatment and Neoadjuvant or Adjuvant ChemotherapyDanciu, Oana, CAdultsNational Surgical Adjuvant Breast and Bowel ProjectBreast - Female; Breast - Male NCT02032823
STM-03: Phase I Study of PAC-1 in the Treatment of Advanced Hematologic Malignancy or Solid TumorsDanciu, Oana, CAdultsVanquish Oncology, Inc.Anus; Bladder; Bones and Joints; Brain and Nervous System; Breast - Female; Breast - Male; Cervix Uteri; Colon; Corpus Uteri; Esophagus; Eye and Orbit; Hodgkin's Lymphoma; Kidney; Larynx; Leukemia, not otherwise specified; Leukemia, other; Lip, Oral Cavity and Pharynx; Liver; Lung; Lymphoid Leukemia; Melanoma, skin; Multiple Myeloma; Mycosis Fungoides; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma; Other Digestive Organ; Other Endocrine System; Other Female Genital; Other Hematopoietic; Other Male Genital; Other Respiratory and Intrathoracic Organs; Other Skin; Other Urinary; Ovary; Pancreas; Prostate; Rectum; Small Intestine; Soft Tissue; Stomach; Thyroid NCT02355535
BTCRC-BRE15-016: A Single Arm Phase II Study OF Palbociclib In Combination with Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast CancerDanciu, Oana, CAdultsBig Ten Cancer Research ConsortiumBreast - Female NCT02668666
NRG-BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast CancerDanciu, Oana, CAdultsNRG OncologyBreast - Female NCT02488967
A011502: A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2 Negative Breast Cancer: The ABC TrialDanciu, Oana, CAdultsAllianceBreast - Female NCT02927249
S1418: A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With Greater than or Equal to 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant ChemotherapyDanciu, Oana, CAdultsSouthwest Oncology GroupBreast - Female NCT02954874
A011401: Randomized Phase III Trial Evaluating The Role Of Weight Loss In Adjuvant Treatment Of Overweight And Obese Women With Early Breast CancerDanciu, Oana, CAdultsAllianceBreast - Female NCT02750826
EAY-131: Molecular Analysis for Therapy Choice (MATCH)Danciu, Oana, CAdultsEastern Cooperative Oncology GroupBladder; Brain and Nervous System; Breast - Female; Breast - Male; Colon; Esophagus; Hodgkin's Lymphoma; Ill-Defined Sites; Kidney; Larynx; Leukemia, not otherwise specified; Liver; Lung; Lymphoid Leukemia; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma; Other Digestive Organ; Other Endocrine System; Other Male Genital; Other Respiratory and Intrathoracic Organs; Other Urinary; Pancreas; Prostate; Rectum; Soft Tissue; Stomach; Thyroid; Unknown Sites NCT02465060
EAY131-K1: Molecular Analysis for Therapy Choice (MATCH): MATCH Treatment Subprotocol K1: EAY131-K1: Phase 2 Study of JNJ-42756493 (erdafitinib) in Patients with Tumors with FGFR AmplificationsDanciu, Oana, CAdultsEastern Cooperative Oncology Group NCT02465060
BTCRC-LUN15-017: Phase II Study of Anti-PD-1 Antibody Pembrolizumab and Imprime PGG for Patients with Non-small Cell Lung Cancer Who Progressed after First Line ChemotherapyFeldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03003468
BTCRC-LUN15-029: A Phase II Trial of Chemotherapy plus Pembrolizumab in Patients with Advanced NSCLC Previously Treated With PD-1 or PD-L1 InhibitorFeldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03083808
BTCRC-LUN16-081: Phase II Study of Consolidation Immunotherapy with Nivolumab and Ipilimumab or Nivolumab alone following Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC)Feldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03285321
IDR-OM-02: A Pivotal, Double-Blind, Randomized, Placebo-Controlled, Multinational Study of SGX942 (Dusquetide) for the Treatment of Oral Mucositis in Patients being Treated with Concomitant Chemoradiation for the Treatment of Squamous Cell Carcinoma of the Head and NeckFeldman, LawrenceAdultsSoligenix, IncLip, Oral Cavity and Pharynx NCT03237325
A221504-Randomized, Double Blind Placebo Controlled Pilot Study of an Oral Selective Peripheral Opioid Receptor Antagonist in Advanced NSCLC (Adenocarcinoma)Feldman, LawrenceAdultsAllianceLung NCT03087708
EA5161 Randomized Phase II Clinical Trial of Cisplatin/Carboplatin & Etoposide (CE) alone or in Combination with Nivolumab as Frontline Therapy for Extensive Stage Small Cell Lung Cancer (ED-SCLC)Feldman, LawrenceAdultsEastern Cooperative Oncology GroupLung NCT03382561
Feasibility and Acceptability of a Fertility Preservation Decision Support Aid for Young Women with Cancer: An Intervention Development Pilot StudyHershberger, PatriciaAdultsUniversity of Illinois at Chicago (UIC)Anus; Bladder; Bones and Joints; Brain and Nervous System; Breast - Female; Breast - Male; Cervix Uteri; Colon; Corpus Uteri; Esophagus; Eye and Orbit; Hodgkin's Lymphoma; Ill-Defined Sites; Kaposi's sarcoma; Kidney; Larynx; Leukemia, not otherwise specified; Leukemia, other; Lip, Oral Cavity and Pharynx; Liver; Lung; Lymphoid Leukemia; Melanoma, skin; Multiple Myeloma; Mycosis Fungoides; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma; Other Digestive Organ; Other Endocrine System; Other Female Genital; Other Hematopoietic; Other Male Genital; Other Respiratory and Intrathoracic Organs; Other Skin; Other Urinary; Ovary; Pancreas; Prostate; Rectum; Small Intestine; Soft Tissue; Stomac
NRG-BR002: A Phase IIR/III Trial of Standard of Care Therapy with or without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast CancerHoskins, KentAdultsNRG OncologyBreast - Female; Breast - Male NCT02364557
PALLAS (AFT-05): Phase III Trial of Palbociclib with Adjuvant Endocrine Therapy versus Endocrine Therapy Alone for Hormone Receptor Positive (HR+)/HER2-negative Early Breast CancerHoskins, KentAdultsAlliance Foundation Trials (AFT)Breast - Female; Breast - Male NCT02513394
Creating a Culturally-Tailored Intervention to Improve Uptake of Genetic Counseling Among Underserved African American Women with Increased Breast Cancer RiskHoskins, KentAdultsNational Cancer InstituteBreast - Female
NSABP B-51: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant ChemotherapyHoskins, KentAdultsNational Surgical Adjuvant Breast and Bowel ProjectBreast - Female NCT01872975
BTCRC-BRE15-024: A Phase I/II, Single Arm, Non-randomized Study of Ribociclib (LEE011), a CDK 4/6 Inhibitor, in Combination w/Bicalutamide, an Androgen Receptor (AR) Inhibitor, in Advanced AR+ Triple-negative Breast CancerHoskins, KentAdultsBig Ten Cancer Research ConsortiumBreast - Female NCT03090165
PATINA (AFT-38): A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy after Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast CancerHoskins, KentAdultsAlliance Foundation Trials (AFT)Breast - Female NCT02947685
S1501: Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients with Metastatic HER-2+ Breast Cancer, Phase IIIHoskins, KentAdultsSouthwest Oncology GroupBreast - Female NCT03418961
A221505 Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation with Breast ReconstructionHoskins, KentAdultsAllianceBreast - Female NCT03414970
A011106 Alternate approaches for clinical stage II or III estrogen receptor positive breast cancer neo-adjuvant treatment in post menopausal women: Phase III studyHoskins, KentAdultsAllianceBreast - Female NCT01953588
OncoNova 04-30: Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician's Choice of Treatment in Patients with Myelodysplastic Syndrome After Failure of a Hypomethylating AgentKhan, IrumAdultsOnconovaMyeloid and Monocytic Leukemia NCT02562443
Effects of Stellate Ganglion Block on Vasomotor Symptoms in Women Receiving Anti-Estrogen Therapy for Breast CancerMaki, PaulineAdultsNorthwestern UniversityBreast - Female NCT02513329
A061202: A Phase I/II Study Of Pomalidomide, Dexamethasone And Ixazomib Vs. Pomalidomide And Dexamethasone For Patients With Multiple Myeloma Refractory To Lenalidomide And Proteasome Inhibitor-Based TherapyPatel, Pritesh, RAdultsAllianceMultiple Myeloma NCT02004275
CA209901 A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial CancerPeace, David, JAdultsBristol-Myers SquibbBladder NCT03036098
BTCRC-GU16-043: Single Arm Phase Ib/II Study of Durvalumab and Guadecitabine in Advanced Kidney CancerPeace, David, JAdultsBig Ten Cancer Research ConsortiumKidney NCT03308396
HCRN GU16-260: Phase II Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell CarcinomaPeace, David, JAdultsBig Ten Cancer Research ConsortiumKidney NCT03117309
E1910: A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-negative B lineage Acute Lymphoblastic Leukemia in AdultsQuigley, John (Sean)AdultsEastern Cooperative Oncology GroupLymphoid Leukemia NCT02003222
BMT-05: A Phase II Study of Intensity Modulated Total Marrow Irradiation (TMI) in Addition to Fludarabine/ Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic SyndromesRondelli, DamianoAdultsUniversity of Illinois at Chicago (UIC)Leukemia, not otherwise specified; Leukemia, other; Lymphoid Leukemia; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma NCT03121014
A Phase III Randomized Open-label Multi-center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid-refractory Chronic Graft vs Host Disease After Allogenic Stem Cell Transplantation (REACH 3)Rondelli, DamianoAdultsIncyte CorporationOther Hematopoietic NCT03112603
GRAVITAS-301: A Randomized, Double-Blind, Placebo Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft Versus Host DiseaseRondelli, DamianoAdultsIncyte CorporationOther Hematopoietic NCT03139604
ACNS0831: Phase III Randomized Trial of Post-Radiation Chemotherapy in patients with Newly Diagnosed Ependymoma Ages 1 to 21 yearsSchmidt, Mary LouBothChildren's Oncology GroupBrain and Nervous System NCT01096368
ALTE07C1: Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with CancerSchmidt, Mary LouBothChildren's Oncology GroupBrain and Nervous System NCT00772200
AALL1131: A Phase III Randomized Trial for Newly Diagnosed High Risk B-precursor Acute Lymphoblastic Leukemia (ALL) Testing Clofarabine (IND#73789, NSC#606869) in the Very High Risk StratumSchmidt, Mary LouBothChildren's Oncology GroupLeukemia, other; Lymphoid Leukemia NCT01406756
ACCL1033: A Comprehensive Approach to Improve Medication Adherence in Pediatric ALLSchmidt, Mary LouBothChildren's Oncology GroupLeukemia, other; Lymphoid Leukemia NCT01503632
ACNS1123: Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)Schmidt, Mary LouBothChildren's Oncology GroupBrain and Nervous System NCT01602666
ANHL12P1, A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, ANHL12P1, NSC# 749710), or Crizotinib (NSC#749005, commercially labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL) IND # 117117Schmidt, Mary LouBothChildren's Oncology GroupNon-Hodgkin's Lymphoma NCT01979536
ANBL1232: Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk NeuroblastomaSchmidt, Mary LouChildrenChildren's Oncology GroupBrain and Nervous System NCT02176967
AALL1331:Risk-Stratified Randomized Phase III Testing of Blinatumomab (IND#117467, NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)Schmidt, Mary LouBothChildren's Oncology GroupLymphoid Leukemia NCT02101853
AEWS1221: Randomized Phase II Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# 750008, IND# 120449) to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing SarcomaSchmidt, Mary LouBothChildren's Oncology GroupSoft Tissue NCT02306161
AHOD1331, A Randomized Phase III Study of Brentuximab vedotin (IND #117117) for Newly Diagnosed Classical Hodgkin Lymphoma (cHL) in Children and AdolescentsSchmidt, Mary LouBothChildren's Oncology GroupHodgkin's Lymphoma NCT02166463
ALTE11C2: Health Effects after Anthracycline and Radiation Therapy (HEART): Dexrazoxane and Prevention of Anthracycline-related CardiomyopathySchmidt, Mary LouBothChildren's Oncology GroupHodgkin's Lymphoma; Ill-Defined Sites; Leukemia, not otherwise specified; Leukemia, other; Lymphoid Leukemia; Melanoma, skin NCT01790152
AALL15P1: A Groupwide Pilot Study to Test the Tolerability and Biologic Activity of the Addition of Azacitidine to Chemotherapy in Infants with Acute Lymphoblastic Leukemia (ALL) and KMT2A (MLL) Gene RearrangementSchmidt, Mary LouChildrenChildren's Oncology GroupLeukemia, other; Lymphoid Leukemia NCT02828358
ACNS1422: A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma PatientsSchmidt, Mary LouBothChildren's Oncology GroupBrain and Nervous System; Eye and Orbit NCT02724579
ALTE1621, Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure (PREVENT-HF):A Phase 2bRandomized Placebo -Controlled (Carvedilol) TrialSchmidt, Mary LouBothChildren's Oncology GroupOther Respiratory and Intrathoracic Organs NCT02717507
ALTE16C1, Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of OsteosarcomaSchmidt, Mary LouAdultsChildren's Oncology GroupBones and Joints NCT03206450
ANBL1531, A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL) (IND# 134379)Schmidt, Mary LouBothChildren's Oncology GroupIll-Defined Sites NCT03126916
Investigational Oocyte Cryopreservation for Medical and Non Medical IndicationsScoccia, HumbertoAdultsUniversity of Illinois at Chicago (UIC)Ovary
Exploring The Use Of Electronic Medication Monitors To Support Adherence In Cancer PatientsSharp, LisaAdultsUniversity of Illinois at Chicago (UIC)Hodgkin's Lymphoma; Leukemia, not otherwise specified; Leukemia, other; Lymphoid Leukemia; Multiple Myeloma; Mycosis Fungoides; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma; Other Hematopoietic
BMT-07: Pilot Study to Determine Target Melphalan Exposure in Patients with Multiple Myeloma Undergoing Autologous Stem Cell TransplantationSweiss, KarenAdultsUniversity of Illinois at Chicago (UIC)Leukemia, not otherwise specified; Lymphoid Leukemia; Multiple Myeloma; Myeloid and Monocytic Leukemia; Non-Hodgkin's Lymphoma
Diet Modulation of Bacterial Sulfur & Bile Acid Metabolism and Colon Cancer RiskTussing-Humphreys, LisaAdultsNational Cancer InstituteColon NCT03550885
NCCTG N1048: A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal ExcisionVenepalli, Neeta, KAdultsNorth Central Cancer Treatment GroupRectum NCT01515787
RTOG 1112: Randomized Phase III Study of Sorafenib Versus Sterotactic Body Radiation Therapy Followed by Sorafenib in Hepatocellular CarcinomaVenepalli, Neeta, KAdultsRadiation Therapy Oncology GroupLiver NCT01730937