Search for Clinical Trials

Clinical trials are research studies designed to answer scientific questions and discover better ways to prevent, diagnose or treat various diseases and conditions, including cancer. A clinical trial is one of the final stages of a long and careful cancer research process. Scientists begin by developing and testing new ideas in a laboratory. If an approach seems promising, the next step may be testing a treatment in animals to learn how it affects cancer in a living being, and whether it has harmful effects.

Treatments that work well in the lab or in animals, however, may not always work well in people. When the potential treatment is deemed safe enough to explore its effects on humans, it proceeds to be studied in a clinical trial. In the context of cancer, these trials are performed with cancer patients to learn whether promising treatments are safe and effective.

What are Clinical Trials?

Clinical trials are divided into four phases:

  • Phase 1 – These studies are to find the same does of a drug, to decide how a potential new treatment should be given, or to see how a potential new treatment affect the human body and fights cancer.
  • Phase 2 – These studies are to determine if a potential new treatment has an effect on a certain cancer and to see how it affects the human body and fights cancer.
  • Phase 3 –Phase III studies compare a new potential treatment with the current standard treatment.
  • Phase 4 – Phase 4 studies study the long-term safety and effectiveness of new treatments.  They take place after the treatment has been approved by the US Food and Drug Administration (FDA) and is on the market.

The most successful cancer treatments today are based on what we have learned from clinical trials. As a result, people with cancer are living longer, with a better quality of life. Participating in clinical trials at the University of Illinois Cancer Center may not only benefit you, but it could also help future patients through the development of newer, safer treatments.

For more information about cancer clinical trials, please see the following resources: National Cancer Institute (NCI), Clinical Trials Information for Patients and CaregiversThe American Cancer Society, Clinical TrialsCancer Support Community, Cancer Clinical clinical trials database.

Below is a listing of UI Cancer Center clinical studies currently enrolling participants.  Click on the dropdown menu below to filter the list by the site of your disease.  If you are interested in participating in a trial listed, please email or call 312-355-5112.

For more information on the study, click on the ID, if available.
For a list of clinical trials nationwide, please see

Study Title Researcher Adult/Children Sponsor Disease Site ID
S1602: A Phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG‐Nave High‐Grade Non‐Muscle Invasive Bladder CancerAbern, Michael RyanAdultsSouthwest Oncology GroupUrinary Bladder NCT03091660
A031501: Phase III Randomized Adjuvant Study Of MK-3475 (Pembrolizumab) In Muscle Invasive And Locally Advanced Urothelial Carcinoma (Ambassador) Versus ObservationAbern, Michael RyanAdultsAllianceUrinary Bladder NCT03244384
Arterial Function and the Effect of Acute Aerobic Exercise in Breast Cancer Survivors.Baynard, TracyAdultsUniversity of Illinois at Chicago (UIC)Breast – Female
A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract CancersChowdhery, RozinaAdultsSouthwest Oncology GroupLiver; Other Digestive Organ NCT03768414
ARRAY-818-103: Phase I Drug-Drug Interaction (DDI) Study with Encorafenib and Binimetinib in Patients with BRAF V600E-Mutant Melanoma or Other Advanced Solid Tumors with the BRAF V600E-MutationChowdhery, RozinaAdultsArray Biopharma Inc.Unknown Sites NCT03864042
BTCRC-GI15-015: A Phase II Study of FOLFOX combined with Nab-Paclitaxel (FOLFOX-A) in the Treatment of Metastatic or Advanced Unresectable Gastric, Gastro-Esophageal Junction AdenocarcinomaChowdhery, RozinaAdultsBig Ten Cancer Research ConsortiumEsophagus; Stomach NCT03283761
A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast CancerDanciu, Oana, CAdultsBreast – Female; Breast – Male NCT03199885
EAY131 Z1H: Phase II Study of Copanlisib in Patients with Tumors with Deleterious PTEN Sequencing Result and PTEN Expression by IHCDanciu, Oana, CAdultsECOG-ACRIN NCT02465060
EAY131-Z1G: Phase II Study of Copanlisib in Patients with Tumors with PTEN Loss by IHC and any PTEN Sequencing ResultDanciu, Oana, CAdultsECOG-ACRIN NCT02465060
EAY131 Z1E: LOXO-101 in Patients with Tumors with NTRK FusionsDanciu, Oana, CAdultsECOG-ACRIN NCT02465060
S1706: A Phase II Randomized Trial of Olaparib (NSC-747856) Administered Concurrently With Radiotherapy Versus Radiotherapy Alone for Inflammatory Breast CancerDanciu, Oana, CAdultsSouthwest Oncology GroupBreast – Female; Breast – Male NCT03598257
C3441020: A Phase 2, Non-Randomized, Open Label, Single Arm, Multi-Center_x000D_ Study of Talazoparib For Neoadjuvant Treatment of Germline BRCA1/2 Mutation Patients with Early Triple-Negative Breast CancerDanciu, Oana, CAdultsPfizer IncBreast – Female; Breast – Male NCT03499353
EAY131: Molecular Analysis for Therapy Choice (MATCH)Danciu, Oana, CAdultsEastern Cooperative Oncology GroupBrain and Nervous System; Breast – Female; Breast – Male; Colon; Esophagus; Hodgkin’s Lymphoma; Ill-Defined Sites; Kidney; Larynx; Leukemia, not otherwise specified; Liver; Lung; Lymphoid Leukemia; Myeloid and Monocytic Leukemia; Non-Hodgkin’s Lymphoma; Other Digestive Organ; Other Endocrine System; Other Male Genital; Other Respiratory and Intrathoracic Organs; Other Urinary; Pancreas; Prostate; Rectum; Soft Tissue; Stomach; Thyroid; Unknown Sites; Urinary Bladder NCT02465060
A011401: Randomized Phase III Trial Evaluating The Role Of Weight Loss In Adjuvant Treatment Of Overweight And Obese Women With Early Breast CancerDanciu, Oana, CAdultsAllianceBreast – Female NCT02750826
S1418: A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With Greater than or Equal to 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant ChemotherapyDanciu, Oana, CAdultsSouthwest Oncology GroupBreast – Female NCT02954874
A011502: A Randomized Phase III Double Blinded Placebo Controlled Trial of Aspirin as Adjuvant Therapy for Node Positive HER2 Negative Breast Cancer: The ABC TrialDanciu, Oana, CAdultsAllianceBreast – Female NCT02927249
NRG-BR003: A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast CancerDanciu, Oana, CAdultsNRG OncologyBreast – Female NCT02488967
BTCRC-BRE15-016: A Single Arm Phase II Study OF Palbociclib In Combination with Tamoxifen as First Line Therapy for Metastatic Hormone Receptor Positive Breast CancerDanciu, Oana, CAdultsBig Ten Cancer Research ConsortiumBreast – Female NCT02668666
STM-03: Phase I Study of PAC-1 in the Treatment of Advanced Hematologic Malignancy or Solid TumorsDanciu, Oana, CAdultsVanquish Oncology, Inc.Anus; Bones and Joints; Brain and Nervous System; Breast – Female; Breast – Male; Cervix; Colon; Corpus Uteri; Esophagus; Eye and Orbit; Hodgkin’s Lymphoma; Kidney; Larynx; Leukemia, not otherwise specified; Leukemia, other; Lip, Oral Cavity and Pharynx; Liver; Lung; Lymphoid Leukemia; Melanoma, skin; Multiple Myeloma; Mycosis Fungoides; Myeloid and Monocytic Leukemia; Non-Hodgkin’s Lymphoma; Other Digestive Organ; Other Endocrine System; Other Female Genital; Other Hematopoietic; Other Male Genital; Other Respiratory and Intrathoracic Organs; Other Skin; Other Urinary; Ovary; Pancreas; Prostate; Rectum; Small Intestine; Soft Tissue; Stomach; Thyroid; Urinary Bladder NCT02355535
Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III TrialFeldman, LawrenceAdultsNRG OncologyLung NCT03137771
BTCRC LUN17-139: A Phase II Study of Carboplatin Plus Pemetrexed Plus Atezolizumab Plus Bevacizumab in Chemotherapy and Immunotherapy-nave Patients With Stage IV Non-squamous Non-small Cell Lung Cancer: Big Ten Cancer Research ConsortiumFeldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03713944
AFT-28: Direct Oral Anticoagulants (DOACs) versus LMWH +/- Warfarin for VTE in Cancer: A Randomized Effectiveness Trial (CANVAS Trial)Feldman, LawrenceAdultsAlliance Foundation Trials (AFT)Breast – Female; Colon; Kidney; Larynx; Liver; Lung; Lymphoid Leukemia; Multiple Myeloma; Other Digestive Organ; Other Respiratory and Intrathoracic Organs; Pancreas; Prostate; Soft Tissue; Stomach NCT02744092
A211401-Reducing Surgical Complications in Newly Diagnosed Lung Cancer Patients who Smoke CigarettesFeldman, LawrenceAdultsAllianceLung NCT02856581
A221504-Randomized, Double Blind Placebo Controlled Pilot Study of an Oral Selective Peripheral Opioid Receptor Antagonist in Advanced NSCLC (Adenocarcinoma)Feldman, LawrenceAdultsAllianceLung NCT03087708
RiMO-CL17-001: Phase I Dose-Escalating Study of RiMO-301 with Radiation in Advanced TumorsFeldman, LawrenceAdultsUniversity of ChicagoAnus; Bones and Joints; Brain and Nervous System; Breast – Female; Breast – Male; Cervix; Colon; Corpus Uteri; Esophagus; Eye and Orbit; Hodgkin’s Lymphoma; Ill-Defined Sites; Kaposi’s sarcoma; Kidney; Larynx; Lip, Oral Cavity and Pharynx; Liver; Lung; Lymphoid Leukemia; Melanoma, skin; Multiple Myeloma; Non-Hodgkin’s Lymphoma; Other Digestive Organ; Other Endocrine System; Other Female Genital; Other Male Genital; Other Respiratory and Intrathoracic Organs; Other Skin; Other Urinary; Ovary; Pancreas; Prostate; Rectum; Small Intestine; Soft Tissue; Stomach; Urinary Bladder NCT03444714
IDR-OM-02: A Pivotal, Double-Blind, Randomized, Placebo-Controlled, Multinational Study of SGX942 (Dusquetide) for the Treatment of Oral Mucositis in Patients being Treated with Concomitant Chemoradiation for the Treatment of Squamous Cell Carcinoma of the Head and NeckFeldman, LawrenceAdultsSoligenix, IncLip, Oral Cavity and Pharynx NCT03237325
BTCRC-LUN16-081: Phase II Study of Consolidation Immunotherapy with Nivolumab and Ipilimumab or Nivolumab alone following Concurrent Chemoradiotherapy for Unresectable Stage IIIA/IIIB Non-small Cell Lung Cancer (NSCLC)Feldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03285321
A Phase II Trial of Chemotherapy plus Pembrolizumab in Patients with Advanced NSCLC Previously Treated With PD-1 or PD-L1 InhibitorFeldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03083808
BTCRC-LUN15-017: Phase II Study of Anti-PD-1 Antibody Pembrolizumab and Imprime PGG for Patients with Non-small Cell Lung Cancer Who Progressed after First Line ChemotherapyFeldman, LawrenceAdultsBig Ten Cancer Research ConsortiumLung NCT03003468
An International, Phase 2, Open-Label, Randomized Study of BGB-3111 Combined with Obinutuzumab Compared With Obinutuzumab Monotherapy in Relapsed/Refractory Follicular LymphomaGalvin, John, PatrickAdultsBeiGene LtdLymphoid Leukemia NCT03332017
Building a Cancer Survivor Support NetworkHamlish, TamaraAdultsUniversity of Illinois at Chicago (UIC)Anus; Breast – Female; Colon; Corpus Uteri; Lung; Other Female Genital; Other Male Genital; Ovary; Prostate; Rectum; Urinary Bladder
A031102: A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell TumorsHo, Dominic, SAdultsAllianceOther Female Genital; Other Male Genital; Ovary NCT02375204
MA-39: TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast CancerHoskins, KentAdultsCCTGBreast – Female NCT03488693
A211601: Evaluation of Mammographic Breast Density Effect of Aspirin: A Companion Study to Alliance Study A011502Hoskins, KentAdultsAllianceBreast – Female; Breast – Male NCT03609021
A221505 Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation with Breast ReconstructionHoskins, KentAdultsAllianceBreast – Female NCT03414970
S1501: Prospective Evaluation of Carvedilol in Prevention of Cardiac Toxicity in Patients with Metastatic HER-2+ Breast Cancer, Phase IIIHoskins, KentAdultsSouthwest Oncology GroupBreast – Female NCT03418961
PATINA (AFT-38): A Randomized, Open Label, Phase III Trial to Evaluate the Efficacy and Safety of Palbociclib + Anti-HER2 Therapy + Endocrine Therapy vs. Anti-HER2 Therapy + Endocrine Therapy after Induction Treatment for Hormone Receptor Positive (HR+)/HER2-Positive Metastatic Breast CancerHoskins, KentAdultsAlliance Foundation Trials (AFT)Breast – Female NCT02947685
NSABP B-51: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant ChemotherapyHoskins, KentAdultsNational Surgical Adjuvant Breast and Bowel ProjectBreast – Female NCT01872975
Creating a Culturally-Tailored Intervention to Improve Uptake of Genetic Counseling Among Underserved African American Women with Increased Breast Cancer RiskHoskins, KentAdultsNational Cancer InstituteBreast – Female
Factors Influencing Surveillance Mammography Adherence and Quality of Life_x000D_ Among Korean Breast Cancer Survivors_x000D_Jang, Min KyeongAdultsUniversity of Illinois at Chicago (UIC)Breast – Female
A Randomized Phase II/III Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults With Acute Myeloid Leukemia Receiving Intensive Induction ChemotherapyKhan, IrumAdultsAllianceMyeloid and Monocytic Leukemia NCT03701308
A Two-Part, Randomized, Open-label, Multicenter, Phase 2a/2b_x000D_ Study of the Efficacy, Safety, and Pharmacokinetics of KRT-232_x000D_ Compared to Ruxolitinib in Patients with Phlebotomy-Dependent_x000D_ Polycythemia VeraKhan, IrumAdultsKartos Therapeutics, IncOther Hematopoietic NCT03669965
An Open-Label, Phase 2a/2b Study of KRT-232 in Subjects With Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post-ET-MF) Who Have Failed a JAK InhibitorKhan, IrumAdultsKartos Therapeutics, IncMultiple Myeloma; Myeloid and Monocytic Leukemia; Other Hematopoietic NCT03662126
OncoNova 04-30: Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome After Failure of a Hypomethylating AgentKhan, IrumAdultsOnconovaMyeloid and Monocytic Leukemia NCT02562443
Behavioral and Neurophysiological Assessment of Hot and Cold Memory and Executive Function in Treated Breast Cancer PatientsKlumpp, HeideAdultsUniversity of Illinois at Chicago (UIC)
Effects of Stellate Ganglion Block on Vasomotor Symptoms in Women Receiving Anti-Estrogen Therapy for Breast CancerMaki, PaulineAdultsNorthwestern UniversityBreast – Female NCT02513329
Assessing and Modeling Network-level Consequences of Patient NavigationMolina, YamileAdultsNational Cancer InstituteBreast – Female
S1802: Phase III Randomized Trial of Standard Systemic Therapy (SST) Versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate CancerMoreira, DanielAdultsSouthwest Oncology GroupProstate NCT03678025
Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II MeningiomaNicholas, Martin (Kelly)AdultsNRG OncologyBrain and Nervous System NCT03180268
Brain Up: A Phase I Study of Safety and Tolerability of Acetazolamide With Temozolomide in Adults with Newly Diagnosed MGMT Promoter Methylated Malignant Glioma.Nicholas, Martin (Kelly)AdultsUniversity of ChicagoBrain and Nervous System NCT03011671
A061202: A Phase I/II Study Of Pomalidomide, Dexamethasone And Ixazomib Vs. Pomalidomide And Dexamethasone For Patients With Multiple Myeloma Refractory To Lenalidomide And Proteasome Inhibitor-Based TherapyPatel, Pritesh, RAdultsAllianceMultiple Myeloma NCT02004275
ProSTAR 1205-201: A Phase 1b/2 Study of CPI-1205, a Small Molecule Inhibitor of EZH2, Combined With Enzalutamide or Abiraterone/Prednisone in Patients With Metastatic Castration Resistant Prostate CancerPeace, David, JAdultsConstellation Pharma, IncOther Urinary; Prostate NCT03480646
HEM15-027: Phase I Study of Nivolumab in Combination With Ruxolitinib in Relapsed or Refractory Classical Hodgkin LymphomaPeace, David, JAdultsBig Ten Cancer Research ConsortiumHodgkin’s Lymphoma NCT03681561
HEM15-028: Phase I/II Study of Ixazomib and Romidepsin in Relapsed/ Refractory Peripheral T-cell Lymphoma (PTCL)Peace, David, JAdultsBig Ten Cancer Research ConsortiumOther Hematopoietic NCT03547700
NRG-GU006: A Phase II, Double-Blinded, Placebo-Controlled Randomized Trial of Salvage Radiotherapy with or without Enhanced Anti-Androgen Therapy with Apalutamide in Recurrent Prostate CancerPeace, David, JAdultsNRG OncologyProstate NCT03371719
HCRN GU16-260: Phase II Study of Front Line Therapy With Nivolumab and Salvage Nivolumab + Ipilimumab in Patients With Advanced Renal Cell CarcinomaPeace, David, JAdultsBig Ten Cancer Research ConsortiumKidney NCT03117309
BTCRC-GU16-043: Single Arm Phase Ib/II Study of Durvalumab and Guadecitabine in Advanced Kidney CancerPeace, David, JAdultsBig Ten Cancer Research ConsortiumKidney NCT03308396
CA209901 A Phase 3, Open-label, Randomized Study of Nivolumab Combined with Ipilimumab, or with Standard of Care Chemotherapy, versus Standard of Care Chemotherapy in Participants with Previously Untreated Unresectable or Metastatic Urothelial CancerPeace, David, JAdultsBristol-Myers SquibbUrinary Bladder NCT03036098
A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (>/= 70 Years of Age) With Chronic Lymphocytic Leukemia (CLL)Quigley, John (Sean)AdultsAllianceLymphoid Leukemia NCT03737981
A041501: A Phase III Trial To Evaluate The Efficacy Of The Addition Of Inotuzumab Ozogamicin (A Conjugated Anti-CD22 Monoclonal Antibody) To Frontline Therapy In Young Adults (Ages 18-39) With Newly Diagnosed Precursor B-Cell ALLQuigley, John (Sean)AdultsLymphoid Leukemia NCT03150693
E1910: A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-negative B lineage Acute Lymphoblastic Leukemia in AdultsQuigley, John (Sean)AdultsEastern Cooperative Oncology GroupLymphoid Leukemia NCT02003222
A Phase III Randomized Open-label Multi-center Study of Ruxolitinib vs. Best Available Therapy in Patients with Corticosteroid-refractory Chronic Graft vs Host Disease After Allogenic Stem Cell Transplantation (REACH 3)Rondelli, DamianoAdultsIncyte CorporationOther Hematopoietic NCT03112603
BMT-05: A Phase II Study of Intensity Modulated Total Marrow Irradiation (TMI) in Addition to Fludarabine/ Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic SyndromesRondelli, DamianoAdultsUniversity of Illinois at Chicago (UIC)Leukemia, not otherwise specified; Leukemia, other; Lymphoid Leukemia; Myeloid and Monocytic Leukemia; Non-Hodgkin’s Lymphoma NCT03121014
AGCT1531, A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell TumorsSchmidt, Mary LouBothChildrens Oncology GroupOther Female Genital; Other Male Genital; Ovary NCT03067181
ACNS1721: A Phase 2 Study of Veliparib (ABT-888, IND # 139199) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma (HGG) without H3 K27M or BRAFV600E MutationsSchmidt, Mary LouBothChildren’s Oncology GroupBrain and Nervous System NCT03581292
APEC1621-SC, NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Screening ProtocolSchmidt, Mary LouBothBones and Joints; Brain and Nervous System; Cervix; Kidney; Leukemia, not otherwise specified; Leukemia, other; Liver; Lymphoid Leukemia; Non-Hodgkin’s Lymphoma; Other Female Genital; Other Male Genital; Soft Tissue
ANBL1531, A Phase 3 Study of 131I-Metaiodobenzylguanidine (131I-MIBG) or Crizotinib Added to Intensive Therapy for Children with Newly Diagnosed High-Risk Neuroblastoma (NBL)Schmidt, Mary LouBothChildren’s Oncology GroupSoft Tissue NCT03126916
AALL1631, International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination with Two Different Cytotoxic Chemotherapy BackbonesSchmidt, Mary LouBothChildren’s Oncology GroupLeukemia, not otherwise specified
ALTE16C1, Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma_x000D_Schmidt, Mary LouAdultsChildren’s Oncology GroupBones and Joints NCT03206450
ALTE1621, Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer _x000D_ Survivors at Risk for Heart Failure (PREVENT-HF):A Phase 2b Randomized Placebo Controlled (Carvedilol) TrialSchmidt, Mary LouBothChildren’s Oncology GroupOther Respiratory and Intrathoracic Organs NCT02717507
ARST1431: A Randomized Phase 3 Study of Vincristine, Dactinomycin, Cyclophosphamide (VAC) Alternating with Vincristine and Irinotecan (VI) Versus VAC/VI Plus Temsirolimus (TORI, Torisel, NSC# 683864, IND# 122782) in Patients with Intermediate Risk (IR) Rhabdomyosarcoma (RMS)Schmidt, Mary LouBothChildren’s Oncology GroupBones and Joints; Soft Tissue NCT02567435
ACNS1422: A Phase 2 Study of Reduced Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma PatientsSchmidt, Mary LouBothChildren’s Oncology GroupBrain and Nervous System; Eye and Orbit NCT02724579
AAML1531: Risk-stratified Therapy for Acute Myeloid Leukemia in Down SyndromeSchmidt, Mary LouChildrenChildren’s Oncology GroupLeukemia, other NCT02521493
AALL1331:Risk-Stratified Randomized Phase III Testing of Blinatumomab (IND#117467, NSC#765986) in First Relapse of Childhood B-Lymphoblastic Leukemia (B-ALL)Schmidt, Mary LouBothChildren’s Oncology GroupLymphoid Leukemia NCT02101853
ANBL1232: Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk NeuroblastomaSchmidt, Mary LouChildrenChildren’s Oncology GroupSoft Tissue NCT02176967
ALTE07C1: Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children with CancerSchmidt, Mary LouBothChildren’s Oncology GroupBrain and Nervous System NCT00772200
Investigational Oocyte Cryopreservation for Medical and Non Medical IndicationsScoccia, HumbertoAdultsUniversity of Illinois at Chicago (UIC)Ovary
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Study of ARN-509 in Men With Non-Metastatic (M0) Castration-Resistant Prostate CancerSharifi, RoohollahAdultsAragon Pharmaceuticals, Inc.Prostate
Exploring The Use Of Electronic Medication Monitors To Support Adherence In Cancer PatientsSharp, LisaAdultsUniversity of Illinois at Chicago (UIC)Hodgkin’s Lymphoma; Leukemia, not otherwise specified; Leukemia, other; Lymphoid Leukemia; Multiple Myeloma; Mycosis Fungoides; Myeloid and Monocytic Leukemia; Non-Hodgkin’s Lymphoma; Other Hematopoietic
NRG-HN004: Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Stage III-IVB Head and Neck Cancer with a Contraindication to CisplatinShergill, ArdamanAdultsNRG OncologyEsophagus; Larynx; Lip, Oral Cavity and Pharynx NCT03258554
E4512: A Randomized Phase III Trial for Surgically Resected Early Stage Non-small Cell Lung Cancer: Crizotinib Versus Observation for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion ProteinShergill, ArdamanAdultsECOG-ACRINLung NCT02201992
A081105: Randomized Study of Erlotinib vs Observation in Patients With Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)Shergill, ArdamanAdultsAllianceLung NCT02193282
EA5142: Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) – A Randomized Phase III Study of Nivolumab After Surgical Resection and Adjuvant Chemotherapy in Non-Small Cell Lung CancersShergill, ArdamanAdultsECOG-ACRINLung NCT02595944
Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST)Shergill, ArdamanAdultsAllianceLung NCT02194738
EA3132: Phase II randomized trial of radiotherapy with or without cisplatin for surgically resected squamous cell carcinoma of head and neck (SCCHN) with TP53 sequencingShergill, ArdamanAdultsEastern Cooperative Oncology GroupLip, Oral Cavity and Pharynx NCT02734537
BMT-07: Pilot Study to Determine Target Melphalan Exposure in Patients with Multiple Myeloma Undergoing Autologous Stem Cell TransplantationSweiss, KarenAdultsUniversity of Illinois at Chicago (UIC)Leukemia, not otherwise specified; Lymphoid Leukemia; Multiple Myeloma; Myeloid and Monocytic Leukemia; Non-Hodgkin’s Lymphoma
Diet Modulation of Bacterial Sulfur & Bile Acid Metabolism and Colon Cancer Risk_x000D_Tussing-Humphreys, LisaAdultsNational Cancer InstituteColon NCT03550885
EA 2165: Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal CancerVenepalli, Neeta, KAdultsEastern Cooperative Oncology GroupAnus NCT03233711
NRG-GI004: Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal CancerVenepalli, Neeta, KAdultsNRG OncologyColon; Rectum NCT02997228
A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients With Stage 0-III Colon or Rectal Cancer, Phase III – Preventing Adenomas of the Colon With Eflornithine and Sulindac (PACES)Venepalli, Neeta, KAdultsSouthwest Oncology Group NCT01349881
RTOG 1112: Randomized Phase III Study of Sorafenib Versus Sterotactic Body Radiation Therapy Followed by Sorafenib in Hepatocellular CarcinomaVenepalli, Neeta, KAdultsRadiation Therapy Oncology GroupLiver NCT01730937