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Two major research meetings, the 2025 American Society of Hematology (ASH) Annual Meeting and the San Antonio Breast Cancer Symposium (SABCS), feature work by authors affiliated with the University of Illinois Cancer Center, the University of Illinois Chicago (UIC) and UI Health, the academic health enterprise at UIC that includes the Cancer Center.

Below are lists of those research abstracts for ASH (December 6-9) in Orlando, Florida, and SABCS (December 9-12) in San Antonio, Texas.

Both meetings draw attendees from around the globe. Focused on diseases of the blood, the ASH Annual Meeting and Exposition covers classical and malignant hematology. SABCS is primarily for academic and private physicians and researchers involved in breast cancer in medical, surgical, gynecologic and radiation oncology, as well as patient advocates and other health care professionals. 

ASH Abstracts

• Sasp-driven immune evasion defines a novel African ancestry-associated DLBCL subtype with distinctive molecular and immune vulnerabilities
• Renin-angiotensin-aldosterone system inhibitors exacerbate anemia in sickle cell disease
• First results of exagamglogene autotemcel in pediatric patients aged 5-11 years with transfusion-dependent β-thalassemia or sickle cell disease with recurrent severe vaso-occlusive crises
• Gene expression profiles of the nephron by urine mRNA: A liquid biopsy to investigate molecular changes in sickle cell nephropathy
• A novel prognostic model for predicting mortality in adults with sickle cell disease and severe sinusoidal obstruction
• Jagged-1+ damage-resistant myeloid progenitors initiate the recovery of the bone marrow endothelial-niche
• Multicenter assessment of absolute neutrophil counts (ANC) and white blood cell counts (WBC) in healthy participants with the erythrocyte duffy null phenotype or genotype
• Phase II, single-arm, open-label, multicenter study: Efficacy of adjunctive Bruton’s tyrosine kinase inhibitor (BTKi) zanubrutinib and chimeric antigen receptor (CART) in aggressive B-cell nonhodgkins lymphoma (aNHL)
• Implementing linkage coordination: Patient experiences in the recruitment and engagement in care to impact practice enhancement (RECIPE) for sickle cell disease study
• HIF-1 and HIF-2 pathways in regulation of hepcidin
• Targeting hemolysis and raas: Osivelotor and losartan ameliorate sickle cell renal pathology
• Effects of vaso-occlusive episodes, acute kidney injury, and APOL1 status on urine albumin concentration in patients with sickle cell disease
• Demographic, neurocognitive, disease impact, and social characteristics of patients served by embedded neuropsychological services in an adult sickle cell clinic
• Transferrin and protection from thrombosis in sickle cell disease
• GATA-3 identifies a distinct subset of T-cell prolymphocytic leukemia (T-PLL) and is associated with CCR4 expression
• Daratumumab with dose-adjusted EPOCH feasibility and early efficacy in newly diagnosed plasmablastic lymphoma: AIDS malignancy consortium 105
• Haploidentical hematopoietic stem cell transplantation in adults with severe sickle cell disease: Long-term outcomes using a modified conditioning regimen with peripheral blood stem cells.
• Long-term follow-up demonstrates durable clinical benefits of exagamglogene autotemcel for sickle cell disease with recurrent vaso-occlusive crises: Final results of climb SCD-121
• Feasibility of wearable technology for remote monitoring in high-risk adults with sickle cell disease: Baseline data from the SCD-carre trial
• Pediatric-inspired regimens for ALL are not associated with improved overall survival in US hispanic adult patients
• The impact of environmental air exposues on disease characteristics and outcomes in a cohort of patients with myelofibrosis
• A fellow-led communication skills training (CST) curriculum for hematology/oncology (HO) trainees
• Development of the sickle cell outcome grading system (SCOGS), a novel classification system for sickle cell disease severity
• Uncovering bispecific antibody mechanisms via 3D superresolution imaging of T cell-tumor cell membrane contacts
• Miscalibration of venous thromboembolic risk assessment models across race and ethnicity in medical patients: A cross-model analysis, correction strategy and potential mediators
• A review and analysis of reported global blood and marrow transplantation costs in comparison to macroeconomic factors including gross national income per capita and out-of-pocket health expenditures
• Understanding the menopause transition in sickle cell disease: An analysis of the implementation of the adapted menopause quick 6
• Race/ethnicity reporting and representation in clinical trials presented at plenary and latebreaking abstract sessions at the American society of hematology (ASH) from 2014 to 2024
• Diffuse fractures in a neonate with homozygous UROS C73R congenital erythropoietic porphyria: An unreported phenotype
• Impact of pain sensitization phenotypes on quality of life among adults with sickle cell disease
• Safety analysis of axatilimab in patients with chronic graft-versus-host disease in an expanded access program
• Impact of voxelotor discontinuation on patients with sickle cell disease

SABCS Abstracts

• Emergency Department Breast Cancer Screening Pilot: Improving Access to Screening and Diagnosis for Underserved Populations (PS3-02-28)
• Breast Cancer Index Re-Stratifies 21-Gene Assay Risk Groups for Risk of Recurrence and Extended Endocrine Therapy Benefit: Final Analysis of the BCI Registry Study (PS3-07-24)
• Genomic Drivers of Racial Disparity in HR-Positive Early Breast Cancer (PS3-07-30)
• Acceptability of a Web-Based Narrative Video Intervention to Promote Clinical Trial Decision Making Among Black Women with Breast Cancer (PS4-11-27)
• Distinct Immune and Metabolic Profiles in Latin American Breast Cancer Patients with Obesity Enrolled in FLEX (PS4-09-09)
• A Rare Case of Fibroadenoma After Long-Term Estrogen Therapy in a Transgender Woman (PS5-04-30)
• Flex: From Genomic Profiling to Real-World Insights in 30,000 Patients with Early-Stage Breast Cancer (PS5-09-19)
• 70-Gene Signature High Risk Classification Provides Stronger Prognostic Value Than Histologic Grade in hr+ her2- Early Breast Cancer (PS5-04-19)