Saverio Gentile, PhD

Title & Department

Assistant Professor

Medicine and Medical Specialties

College of Medicine

Research Program

Translational Oncology Program (TO)

Phone: 312-355-2870

Email: sgentile@uic.edu

My lab focus on understanding the role of ion channels in cancer and on developing an anticancer  therapeutic strategy by pharmacological targeting ion channels.   We have discovered that cancer cells (independently of their histogenesis) can aberrantly express specific K+ which render cancers susceptible to targeting and growth arrest. Also, pharmacological targeting K+ channels with selective small molecules already available affect several hallmarks of cancer including cell proliferation and motility, metabolism and drug resistance without significant side effects and potentiates efficacy of drugs that are currently in use for cancer therapy.     Our studies are a key step in translating this innovative approach into an effective targeted therapy that improves outcomes and reduces treatment-related morbidity.

Education

PhD, University Dagli Studi Della Calabria and Stazione Zoological Anton Dohrn Naples

Disease Focus

Breast; Lung; Colorectal; Ovarian

Research Keywords

Ion Channels; Cancer Biology; Drug Resistance; Cancer Cell Proliferation; Metastasis; Metabolism; Cell Signaling; Translational Science

Additional Language(s)

Italian

Published Research

PubMed Search

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