Dr. Natalia Nieto is a Professor in the Department of Pathology at the University of Illinois at Chicago College of Medicine. During her Ph.D., she acquired solid knowledge on the role of oxidative stress, inflammation and steatosis in inflammatory bowel disease.In her first period of Postdoctoral training at the Marion Bessin Liver Research Center at the Albert Einstein College of Medicine, Dr. Nieto worked with Dr. Marcos Rojkind. Her research focused on the role of the extracellular matrix in the pathophysiology of alcoholic liver disease and liver fibrosis. During her second period of Postdoctoral training at the Icahn School of Medicine at Mount Sinai, Dr. Nieto worked with Dr. Arthur Cederbaum where she studied the overall contribution of oxidant stress to alcoholic liver disease and hepatic fibrosis.Through her training, she developed broad expertise on the crosstalk among liver cells in alcohol-induced liver injury and the fibrogenic response, which continues to be the major focus of her research. Upon her arrival at the University of Illinois at Chicago (UIC), she became the Director of the Liver Research Program that has built a network of NIH-funded scientists within our institution with common research interests. In 2012, her laboratory became part of the NIAAA-funded DASH Consortium on Translational Research in Alcoholic Hepatitis by leading one of the exploratory projects (U01 AA021887). In the current application, her laboratory plans to dissect the pathological role of a circulating immunostimulatory complex of hepatic origin as an inducer of tumor necrosis factor- and injury in alcoholic liver disease.Her research is focused on Osteopontin, liver disease, Oxidant stress and liver injury.