Maxim Frolov, PhD

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Maxim Frolov, PhD

Cancer Biology Research Program

Professor
Department of Biochemistry and Molecuclar Genetics
College of Medicine

Email: mfrolov@uic.edu

Maxim Frolov, PhD, is Professor in the Department of Biochemistry and Molecular Genetics at the University of Illinois College Medicine at UIC. His laboratory uses genetic, biochemical and genomic approaches to gain insights into mechanisms that control cell proliferation and differentiation during animal development, with the focus on the Retinoblastoma (RB) pathway. Toward this goal, they take full advantage of the Drosophila genetic model system, which has a streamlined version of the RB pathway. He has worked on the RB pathway since 1999 and has made several contributions to the field using the fly model. Among them are the finding that E2F regulation is a net result of interplay between an activator and a repressor E2Fs, linking the RB pathway to metabolic regulation, pinpointing essential functions of RB during development, use of state of the art single cell genomics to profile mutations in RB pathway, demonstrating functional interaction between intronic microRNAs and the host genes they are embedded into.

Language : English

Education

PhD, Moscow State University

PubMed Search

Research Focus

Cancer Biology
Tumor Suppressor
Cell Cycle
Single Cell Genomics
Genetics
Genomics
Model Systems

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Maxim Frolov, PhD

Cancer Biology Research Program

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