InSug O-Sullivan, PhD

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InSug O-Sullivan, PhD

Cancer Biology Research Program

Research Assistant Professor
Division of Endocrinology, Diabetes, Metabolism
College of Medicine

Email: insug@uic.edu

InSug O-Sullivan, PhD, is Research Assistant Professor in the Division of Endocrinology, Diabetes and Metabolism in the University of Illinois College of Medicine at UIC. She developed metastasis inhibitors that mimic carbohydrate structures of the cancer cell surface to interfere with the metastatic process. She constructed an expression vector for SA-LeA using alpha 1, 3/4 fucosyltransferase (FTIII) that can be stably transfected onto highly metastatic cell lines (e.g., B16F10/FTIII) making them far more metastatic by expressing SA-LeA and SA-LeX. Next, she worked on pre-clinical cancer immunotherapy targeting breast cancer, squamous cell carcinoma in the head and neck (SCCHN), prostate cancer and their metastasized forms in the brain. Tumor-associated antigens (TAA) were introduced to be expressed in plasmid DNA, viral vectors, dendritic cells, or modified fibroblasts to elicit T-cell-mediated cytotoxicity. She identified TRP-2, Cyp2e1, and GRB10 as potential TAAs displaying remarkable anti-tumor immunity without autoimmunity or side effects.

Language : Chinese, English, German, Japanese, Korean

Education

PhD, New York University

PubMed Search

Research Focus

Cancer Biology
Cancer MetabolismFoxo Transcription Factors; Metabolic Disorders; Tumor Associated Antigens; Cancer Vaccines; Breast Cancer; Metastasis
FOXO Transcription FactorsMetastasis
Tumor Associated Antigens; Cancer Vaccines; Breast Cancer;
Cancer Vaccines
Breast Cancer Metastasis

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InSug O-Sullivan, PhD

Cancer Biology Research Program

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