Douglas Thomas, PhD

Title & Department

Associate Professor

Pharmaceutical Sciences

College of Pharmacy

Research Program

Cancer Biology (CB)

Phone: 312-996-6156

Email: ddthomas@uic.edu

The primary focus of this lab is to investigate the myriad of abnormal epigenetic modifications that have been associated with tumor phenotype via tumor suppressor silencing or upregulation of oncogenic proteins. Our approach uses both in vitro and in vivo model systems coupled with a multitude of methodologies including mass spectroscopy, confocal microscopy, electron paramagnetic resonance imaging of free radicals, chemiluminescence, electrochemical, and molecular biology techniques. Specifically we study the free radical signaling molecule nitric oxide (NO). We were the first to identify novel mechanisms of NO signaling by establishing that NO is an endogenous epigenetic regulatory molecule that has significant effects on gene expression via modifying proteins, DNA, and RNA. The current emphasis of our team focuses on genome-wide analysis of molecular events leading to the development and ultimate treatment of breast and brain cancers.

Education

PhD, Louisiana State University Health Sciences Center

Disease Focus

Brain; Breast

Research Keywords

Redox Biology; Epigenetics; Niric Oxide; Tumor Progression; Iron; Breast Cancer; Methylation

Published Research

PubMed Search

Other Link(s)

Department Webpage

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