Dr. Alicia Hulbert
I have been studying cancer epigenetics, DNA Methylation in Lung Cancer diagnostic for 7 years at Sidney Kimmel Cancer Center Johns Hopkins University School of Medicine. My research focuses primarily on studying epigenetic changes in cancer by developing and clinically applying molecular biomarkers, namely DNA methylation, to facilitate the early detection, accurate prognosis and tailor treatment approaches. I have successfully developed, trouble-shouted, validated and patented an ultrasensitive method for early detection of lung cancer based on detection of DNA methylation changes in genes obtained from body fluids (blood, sputum) using methylation specific PCR, in situ MSP, and more recently nanotechnology based detection methods MOB (Methylation on Beads). This has led to molecular detection of cancer epigenetic changes as a method for early detection of lung cancer. My current research aims at utilizing these findings to improve the management of patients through the development of diagnosis, prognostic and predictive epigenetic biomarkers in populations suffering from health disparities. My research and academic experience makes me an ideal scientist to study the aims proposed in this project.