Dr. Maker is a an Associate Professor in the Department of Surgery and Department of Microbiology and Immunology. His research is focused on treating benign and malignant diseases of the liver, bile ducts, gallbladder and pancreas. Dr. Maker also researches colon and other gastrointestinal cancers, melanoma, and sarcoma. His lab research is focused on investigating mechanisms by which to increase lymphocyte proliferation, activation, and anti-tumor responses in colorectal cancer and colorectal cancer liver metastases. As a doctoral fellow at Yale, under the mentorship of the current NIH Program Director, Dr. Dana Andersen, Dr. Maker carried out cell signaling studies in liver tissues from pre-clinical models resulting in an honors dissertation. As a postdoctoral fellow at the NCI under the mentorship of Dr. Steven Rosenberg in the Tumor Immunology section of the Surgery Branch, he was involved in many of the initial clinical trials treating melanoma patients with anti-CTLA4 immunotherapy, cared for these patients and operated on them, while also examining the mechanisms of anti-tumor responses in their tissues.At Memorial Sloan-Kettering Cancer Center, Dr. Maker expanded this research to include investigations into the tumor immunobiology of hepatopancreatobiliary tumors and specifically colorectal liver metastases. Since starting laboratory investigations at the University of Illinois at Chicago, Dr. Maker has built upon his previous work and continued to investigate strategies to enhance anti-tumor immune responses in colorectal liver metastases. This led to society career development awards and then a federally-funded award from the NCI. In his lab, they have created innovative surgical models of colorectal liver metastases and developed strategies to abrogate tumor growth by manipulating immunoregulatory signals in the tumor microenvironment.His research is focused on treating benign and malignant diseases of the liver, bile ducts, gallbladder and pancreas, as well as colon and other gastrointestinal cancers, melanoma, and sarcoma.