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Obesity and Breast Cancer: How Obesity Changes the Microenvironment
January 11 at 10:00 am - 11:00 am
Lisa Arendt, DVM, PhD
Assistant Professor, Department of Comparative Biosciences, School of Veterinary Medicine
University of Wisconsin-Madison
Obesity is a significant risk for breast cancer in postmenopausal women. Regardless of menopausal status, obesity increases the growth of clinically more aggressive breast tumors. Using a novel patient-derived xenograft model as well as a high fat diet model of obesity, we investigated how obesity-induced inflammation enhances aggressive cells within primary tumors, promotes fibrosis within the tumor microenvironment and increases metastasis. Targeting inflammation may significantly enhance therapeutic response in obese breast cancer patients.