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Ekrem Emrah Er, PhD – Metastatic colonization: molecular mechanisms, vulnerabilities and clinical implications

November 26 at 12:00 pm - 1:00 pm

Ekrem Emrah Er, PhD

Assistant Professor, Department of Physiology and Biophysics

University of Illinois at Chicago

 


ABSTRACT

Emergence of life-threatening metastases in vital secondary organs requires disseminated tumor cells to activate mechano-sensitive transcription factors. We found that a subset of these transcription factors that are necessary for cancer cell dissemination paradoxically suppresses overt metastatic outgrowth. Specifically, we found that overexpression of MRTFA and B, which regulate the actin cytoskeleton and cellular migration, compromises cancer cell survival within the metastatic microenvironment. Currently, we are investigating the molecular mechanism by which MRTF expression is coupled to this vulnerability and its implications for patient outcome using immune competent mouse models of breast cancer and melanoma metastasis, biophysical approaches and bioinformatics

 

 

Details

Date:
November 26
Time:
12:00 pm - 1:00 pm
Event Category:

Venue

Molecular Biology Research Building (MBRB), Auditorium
900 S. Ashland Ave. United States + Google Map