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Ekrem Emrah Er, PhD – Metastatic colonization: molecular mechanisms, vulnerabilities and clinical implications
November 26, 2019 @ 12:00 pm - 1:00 pm
Ekrem Emrah Er, PhD
Assistant Professor, Department of Physiology and Biophysics
University of Illinois at Chicago
Emergence of life-threatening metastases in vital secondary organs requires disseminated tumor cells to activate mechano-sensitive transcription factors. We found that a subset of these transcription factors that are necessary for cancer cell dissemination paradoxically suppresses overt metastatic outgrowth. Specifically, we found that overexpression of MRTFA and B, which regulate the actin cytoskeleton and cellular migration, compromises cancer cell survival within the metastatic microenvironment. Currently, we are investigating the molecular mechanism by which MRTF expression is coupled to this vulnerability and its implications for patient outcome using immune competent mouse models of breast cancer and melanoma metastasis, biophysical approaches and bioinformatics